Design of a highly sensitive and specific nucleotide sensor based on photon upconverting particles

被引：210

作者：

Zhang, Peng ^{[1
]}

Rogelj, Snezna

Nguyen, Khoi

Wheeler, Damon

机构：

[1] New Mexico Inst Min & Technol, Dept Chem, Socorro, NM 87801 USA

[2] New Mexico Inst Min & Technol, Lab Nanomat Sci, Socorro, NM 87801 USA

[3] New Mexico Inst Min & Technol, Dept Biol, Socorro, NM 87801 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 38期

关键词：

D O I：

10.1021/ja0644024

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We have designed and developed a novel sensor that reports the presence of specific nucleic acids in solutions, based on photon upconverting particles. The significantly high signal-to-noise ratio of photon upconverting particles leads to high sensitivity of the sensor. The sensor does not suffer from photobleaching. It also displays high specificity and self-calibrating capability. We expect nucleotide sensors of this type to be effective for applications in both DNA/RNA detection and protein-DNA/RNA interaction studies. Copyright © 2006 American Chemical Society.

引用

页码：12410 / 12411

页数：2

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