Interruption of antiretroviral therapy to augment immune control of chronic HIV-1 infection: Risk without reward

被引：16

作者：

Abbas, UL ^{[1
]}

Mellors, JW ^{[1
]}

机构：

[1] Univ Pittsburgh, Sch Med, Div Infect Dis, Pittsburgh, PA 15260 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2002年 / 99卷 / 21期

关键词：

D O I：

10.1073/pnas.212518999

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

引用

页码：13377 / 13378

页数：2

共 27 条

[1] Risks and benefits of structured antiretroviral drug therapy interruptions in HIV-1 infection
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[2] Transient mobilization of human immunodeficiency virus (HIV)-specific CD4 T-helper cells fails to control virus rebounds during intermittent antiretroviral therapy in chronic HIV type 1 infection
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[3] Suppression of HIV replication in the resting CD4+ T cell reservoir by autologous CD8+ T cells:: Implications for the development of therapeutic strategies
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Fauci, AS
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (01) : 253 - 258
[4] HIV-1 and T cell dynamics after interruption of highly active antiretroviral therapy (HAART) in patients with a history of sustained viral suppression
Davey, RT
Bhat, N
Yoder, C
Chun, TW
Metcalf, JA
Dewar, R
Natarajan, V
Lempicki, RA
Adelsberger, JW
Millers, KD
Kovacs, JA
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Fauci, AS
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[5] Mutation takes no vacation: Can structured treatment interruptions increase the risk of drug-resistant HIV-1?
Dorman, KS
Kaplan, AH
Lange, K
Sinsheimer, JS
[J]. JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2000, 25 (05) : 398 - 402
[6] Short-cycle structured intermittent treatment of chronic HIV infection with highly active antiretroviral therapy: Effects on virologic, immunologic, and toxicity parameters
Dybul, M
Chun, TW
Yoder, C
Hidalgo, B
Belson, M
Hertogs, K
Larder, B
Dewar, RL
Fox, CH
Hallahan, CW
Justement, JS
Migueles, SA
Metcalf, JA
Davey, RT
Daucher, M
Pandya, P
Baseler, M
Ward, DJ
Fauci, AS
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (26) : 15161 - 15166
[7] The virological and immunological consequences of structured treatment interruptions in chronic HIV-1 infection
García, F
Plana, M
Ortiz, GM
Bonhoeffer, S
Soriano, A
Vidal, C
Cruceta, A
Arnedo, M
Gil, C
Pantaleo, G
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Nixon, DF
Miró, JM
Gatell, JM
[J]. AIDS, 2001, 15 (09) : F29 - F40
[8] Strong human immunodeficiency virus (HIV)-specific CD4+ T cell responses in a cohort of chronically infected patients are associated with interruptions in anti-HIV chemotherapy
Haslett, PAJ
Nixon, DF
Shen, Z
Larsson, M
Cox, WI
Manandhar, R
Donahoe, SM
Kaplan, G
[J]. JOURNAL OF INFECTIOUS DISEASES, 2000, 181 (04) : 1264 - 1272
[9] Pre-HAART HIV burden approximates post-HAART viral levels following interruption of therapy in patients with sustained viral suppression
Hatano, H
Vogel, S
Yoder, C
Metcalf, JA
Dewar, R
Davey, RT
Polis, MA
[J]. AIDS, 2000, 14 (10) : 1357 - 1363
[10] Structured intermittent treatment for HIV disease: Necessary concession or premature compromise?
Havlir, DV
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (01) : 4 - 6

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