Snake venom L-amino acid oxidases

被引：311

作者：

Du, XY ^{[1
]}

Clemetson, KJ ^{[1
]}

机构：

[1] Univ Bern, Theodor Kocher Inst, CH-3012 Bern, Switzerland

来源：

TOXICON | 2002年 / 40卷 / 06期

关键词：

L-amino acid oxidase; snake venom; hydrogen peroxide; platelet aggregation; apoptosis;

D O I：

10.1016/S0041-0101(02)00102-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

L-amino acid oxidases are widely found in snake venoms and are thought to contribute to the toxicity upon envenomation. The mechanism of these toxic effects and whether they result from the enzymatic activity are still uncertain although many papers describing the biological and pharmacological effects of L-amino acid oxidases have appeared recently, which provide more information about their action on platelets, induction of apoptosis, haemorrhagic effects, and cytotoxicity. This review summarizes the physiochemical properties, structural characteristics and various biological functions of snake venom L-amino acid oxidases (SV-LAAOs). In addition, the putative mechanisms of SV-LAAO-induced platelet aggregation and apoptosis of cells are discussed in more detail. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：659 / 665

页数：7

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