OPA1 and PARL keep a lid on apoptosis

被引：47

作者：

Gottlieb, Eyal ^{[1
]}

机构：

[1] Beatson Inst Canc Res, Canc Res UK, Apoptosis & Tumour Physiol Lab, Glasgow G61 1BD, Lanark, Scotland

来源：

CELL | 2006年 / 126卷 / 01期

关键词：

D O I：

10.1016/j.cell.2006.06.030

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A change in the shape of mitochondrial cristae must take place to attain rapid and complete release of cytochrome c during apoptosis. In this issue of Cell, Cipolat et al. (2006) and Frezza et al. (2006) show that a rhomboid intramembrane protease PARL and a dynamin-related protein OPA1 are critical regulators of cristae remodeling.

引用

页码：27 / 29

页数：3

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