Immunohistochemical expression of vascular endothelial growth factor (VEGF) and C-KIT in cutaneous melanocytic lesions

被引：30

作者：

Stefanou, D ^{[1
]}

Batistatou, A ^{[1
]}

Zioga, A ^{[1
]}

Arkoumani, E ^{[1
]}

Papachristou, DJ ^{[1
]}

Agnantis, NJ ^{[1
]}

机构：

[1] Univ Ioannina, Dept Pathol, GR-45110 Ioannina, Greece

来源：

INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY | 2004年 / 12卷 / 02期

关键词：

VEGF; c-kit; nevus; melanoma;

D O I：

10.1177/106689690401200206

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Vascular endothelial growth factor (VEGF) and C-KIT are involved in tumor progression in several human neoplasms. The aim of the present Study has been to investigate their immunohistochemical expression in melanocytic lesions. We examined 11 compound nevi, 12 dysplastic nevi, and IS melanomas. Immunostaining for VEGF was observed only in melanomas; c-kit expression was detected in melanomas (higher in radial than in vertical growth phase) and in nevi (predominantly in the junctional component). Our data indicate that assessment of VEGF expression might aid in the differential diagnosis between dystplastic nevi and melanomas. Moreover, VEGF might be a candidate for targeted therapy. The loss of c-kit expression might contribute to melanoma progression.

引用

页码：133 / 138

页数：6

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