Quick onset of severe abdominal pain after codeine in an ultrarapid metabolizer of debrisoquine

被引：96

作者：

Dalen, P ^{[1
]}

Frengell, C ^{[1
]}

Dahl, ML ^{[1
]}

Sjoqvist, F ^{[1
]}

机构：

[1] HUDDINGE UNIV HOSP,DIV CLIN PHARMACOL,DEPT MED LAB SCI & TECHNOL,S-14186 HUDDINGE,SWEDEN

来源：

THERAPEUTIC DRUG MONITORING | 1997年 / 19卷 / 05期

关键词：

cytochrome; P-450; genetics; metabolism;

D O I：

10.1097/00007691-199710000-00011

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

The authors describe a 33-year-old woman who experienced severe pain in the epigastrium after codeine intake. This side-effect is consistent with that of morphine. Later, the patient was phenotyped and genotyped as an ultrarapid metabolizer with high capacity to metabolize codeine to morphine.

引用

页码：543 / 544

页数：2

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