A distinct subset of submucosal mast cells undergoes hyperplasia following neonatal maternal separation: a role in visceral hypersensitivity?

被引：29

作者：

Hyland, N. P. ^{[2
,3
]}

Julio-Pieper, M. ^{[3
]}

O'Mahony, S. M. ^{[3
,4
]}

Bulmer, D. C. ^{[4
]}

Lee, K. ^{[4
]}

Quigley, E. M. ^{[3
,5
]}

Dinan, T. G. ^{[3
,6
]}

Cryan, J. F. ^{[1
,2
,3
,6
]}

机构：

[1] Natl Univ Ireland Univ Coll Cork, Sch Pharm, Cork, Ireland

[2] Natl Univ Ireland Univ Coll Cork, Dept Pharmacol & Therapeut, Cork, Ireland

[3] Natl Univ Ireland Univ Coll Cork, Alimentary Pharmabiot Ctr, Cork, Ireland

[4] GlaxoSmithKline Med Res Ctr, Immunoinflammat CEDD, Stevenage, Herts, England

[5] Natl Univ Ireland Univ Coll Cork, Dept Med, Cork, Ireland

[6] Natl Univ Ireland Univ Coll Cork, Dept Psychiat, Cork, Ireland

来源：

GUT | 2009年 / 58卷 / 07期

关键词：

STRESS; RATS;

D O I：

10.1136/gut.2008.167882

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

引用

页码：1029 / 1030

页数：4

共 4 条

[1] Nerve growth factor mediates alterations of colonic sensitivity and mucosal barrier induced by neonatal stress in rats [J].

Barreau, F ;

Cartier, C ;

Ferrier, L ;

Fioramonti, J ;

Bueno, L .

GASTROENTEROLOGY, 2004, 127 (02) :524-534

[2]

GIBSON S, 1986, IMMUNOLOGY, V58, P101

[3] Mast cells [J].

Metcalfe, DD ;

Baram, D ;

Mekori, YA .

PHYSIOLOGICAL REVIEWS, 1997, 77 (04) :1033-1079

[4] Early Life Stress Alters Behavior, Immunity, and Microbiota in Rats: Implications for Irritable Bowel Syndrome and Psychiatric Illnesses [J].

O'Mahony, Siobhain M. ;

Marchesi, Julian R. ;

Scully, Paul ;

Codling, Caroline ;

Ceolho, Anne-Marie ;

Quigley, Eamonn M. M. ;

Cryan, John F. ;

Dinan, Timothy G. .

BIOLOGICAL PSYCHIATRY, 2009, 65 (03) :263-267

← 1 →