Immunogenicity, safety, and memory of different schedules of Neisseria meningitidis A/C-diphtheria toxoid conjugate vaccine in infants in Niger

被引：26

作者：

Chippaux, JP

Garba, A

Ethevenaux, C

Campagne, G

de Chabalier, F

Djibo, S

Nicolas, P

Ali, H

Charrondière, M

Ryall, R

Bybel, M

Schuchat, A

机构：

[1] CERMES, Niamey, Niger

[2] Aventis Pasteur, F-69367 Lyon 07, France

[3] IMTSSA, F-13998 Marseille, France

[4] Aventis Pasteur, Swiftwater, PA USA

[5] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA

来源：

VACCINE | 2004年 / 22卷 / 25-26期

关键词：

Neisseria meningitidis conjugate vaccine; immunogenicity; safety;

D O I：

10.1016/j.vaccine.2004.02.028

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We studied one to four doses of meningococcal polysaccharides A and C conjugated to diphtheria toxoid (Men D) versus A/C polysaccharide (Men PS) vaccine in 618 infants in Niger. Men PS at 24 months permitted evaluating memory. Two Men D doses (at 3 and 9 months) induced higher serum bactericidal activity (SBA) than other regimens. SBA titers after Men PS at 24 months were higher in those given Men D in infancy versus Men PS. While responses were lower for serogroup C, hyporesponsiveness was not evident. MenD was well-tolerated. A single Men D dose in infancy appeared to induce memory. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：3303 / 3311

页数：9

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