Macropinocytosis as a mechanism of entry into primary human urethral epithelial cells by Neisseria gonorrhoeae

被引：40

作者：

Zenni, MK

Giardina, PC

Harvey, HA

Shao, JQ

Ketterer, MR

Lubaroff, DM

Williams, RD

Apicella, MA

机构：

[1] Univ Iowa, Sch Med, Dept Microbiol, Iowa City, IA 52242 USA

[2] Univ Iowa, Dept Urol, Iowa City, IA 52242 USA

来源：

INFECTION AND IMMUNITY | 2000年 / 68卷 / 03期

关键词：

D O I：

10.1128/IAI.68.3.1696-1699.2000

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Gonococcal entry into primary human urethral epithelial cells (HUEC) fan occur by macropinocytosis. Scanning and transmission electron microscopy revealed lamellipodia surrounding gonococci, and confocal laser scanning microscopy analysis showed organisms colocalized with M-r 70,000 fluorescein isothiocyanate-labeled dextran within the cells. Phosphoinositide 3-kinase inhibitors and an actin polymerization inhibitor prevented macropinocytic entry of gonococci into HUEC.

引用

收藏

页码：1696 / 1699

页数：4

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