Diagnostic value of anti-Saccharomyces cerevisiae and antineutrophil cytoplasmic antibodies for inflammatory bowel disease:: High prevalence in patients with celiac disease

被引:47
作者
Damoiseaux, JGMC
Bouten, B
Linders, AMLW
Austen, J
Roozendaal, C
Russel, MGVM
Forget, PP
Tervaert, JWC
机构
[1] Univ Hosp Maastricht, Dept Clin & Expt Immunol, NL-6202 AZ Maastricht, Netherlands
[2] Univ Hosp Maastricht, Dept Pediat, Maastricht, Netherlands
[3] Univ Groningen Hosp, Dept Immunol, Groningen, Netherlands
[4] Univ Hosp Maastricht, Dept Gastroenterol, Maastricht, Netherlands
关键词
inflammatory bowel disease; autoimmune disease; IgA deficiency;
D O I
10.1023/A:1019926121972
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Both celiac disease and inflammatory bowel disease (IBD) are characterized by chronic diarrhea and the presence of distinct (auto)antibodies. In the present study we wanted to determine the prevalence of serological markers for inflammatory bowel disease, i.e., perinuclear antineutrophil cytoplasmic antibodies (pANCA) and/or anti-Saccharomyces cerevisiae antibodies (ASCA), in 37 patients with biopsy-confirmed celiac disease (Marsh IIIb/c). The majority of the patients was positive for IgA (auto)antibodies typically associated with celiac disease, i.e., antiendomysium antibodies (EMA) (86.5%), antigliadin antibodies (AGA) (73%), and antirecombinant human tissue transglutaminase antibodies (rh-tTGA) (86.5%). Four patients with selective IgA deficiency could be identified by analyzing EMA, AGA, and rh-tTGA for the IgG isotype. The prevalence of pANCA and ASCA, markers that are used for IBD, was unexpectedly high in our cohort of patients with celiac disease: 8 patients were positive for pANCA (IgG) and 16 patients were positive for ASCA (IgG and/or IgA). These results indicate that the presence of pANCA or ASCA in the serum of patients with chronic diarrhea does not exclude celiac disease. A prospective study is required to determine whether pANCA and/or ASCA identify patients at risk for developing secondary autoimmune disease.
引用
收藏
页码:281 / 288
页数:8
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