Developmental regulation of cell migration -: Insights from a genetic approach in Drosophila

被引：14

作者：

Montell, DJ ^{[1
]}

机构：

[1] Johns Hopkins Sch Med, Dept Biol Chem, Baltimore, MD 21205 USA

来源：

CELL BIOCHEMISTRY AND BIOPHYSICS | 1999年 / 31卷 / 03期

关键词：

cell migration; guidance receptors; Rac GTPase; adhesion; myosin; genetics;

D O I：

10.1007/BF02738240

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cell movements are fascinating and dramatic features of normal animal development. Moreover, failures in cell migration can lead to birth defects, and inappropriate cell migration can lead to cancer metastasis. Genetic approaches are beginning to provide some insights into the molecular basis for the developmental regulation of cell migration. This review discusses the progress that has been made in understanding the regulation of cell migration during Drosophila development, using a molecular genetic approach. in particular, these studies have implicated signaling through a receptor tyrosine kinase in the spatial control of migration. Reorganization of the cytoskeleton, under the control of the guanosine triphosphatase, Rac, is also critical for cell migration. Finally, genetic studies have demonstrated that the timing of cell migration is under transcriptional control.

引用

页码：219 / 229

页数：11

共 52 条

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