Autophagy in cancer: Good, bad, or both?

被引：339

作者：

Hippert, Melanie M.

O'Toole, Patrick S.

Thorburn, Andrew

机构：

[1] Univ Colorado Denver & Hlth Sci Ctr, Dept Pharmacol, Aurora, CO 80045 USA

[2] Univ Colorado Denver & Hlth Sci Ctr, Ctr Canc, Aurora, CO 80045 USA

来源：

CANCER RESEARCH | 2006年 / 66卷 / 19期

关键词：

D O I：

10.1158/0008-5472.CAN-06-1597

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Autophagy has been recognized as an important cellular process for at least 50 years; however, it is only with the recent identification of key regulators of autophagy (Atg genes) that we have begun a mechanistic exploration of its importance in cancer. Recent studies suggest that autophagy may be important in the regulation of cancer development and progression and in determining the response of tumor cells to anticancer therapy. However, the role of autophagy in these processes is complicated and may, depending on the circumstances, have diametrically opposite consequences for the tumor. In this article, we discuss recent discoveries regarding autophagy in cancer.

引用

页码：9349 / 9351

页数：3

共 20 条

[1] The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway
Arico, S
Petiot, A
Bauvy, C
Dubbelhuis, PF
Meijer, AJ
Codogno, P
Ogier-Denis, E
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (38) : 35243 - 35246
[2] Inhibition of macroautophagy triggers apoptosis
Boya, P
González-Polo, RA
Casares, N
Perfettini, JL
Dessen, P
Larochette, N
Métivier, D
Meley, D
Souquere, S
Yoshimori, T
Pierron, G
Codogno, P
Kroemer, G
[J]. MOLECULAR AND CELLULAR BIOLOGY, 2005, 25 (03) : 1025 - 1040
[3] Autophagy and signaling: their role in cell survival and cell death
Codogno, P
Meijer, AJ
[J]. CELL DEATH AND DIFFERENTIATION, 2005, 12 (Suppl 2) : 1509 - 1518
[4] The coordinate regulation of the p53 and rnTOR pathways in cells
Feng, ZH
Zhang, H
Levine, AJ
Jin, S
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (23) : 8204 - 8209
[5] Vitamin D analog EB1089 triggers dramatic lysosomal changes and Beclin 1-mediated autophagic cell death
Hoyer-Hansen, M
Bastholm, L
Mathiasen, IS
Elling, F
Jäättelä, M
[J]. CELL DEATH AND DIFFERENTIATION, 2005, 12 (10) : 1297 - 1309
[6] The role of autophagy in cancer development and response to therapy
Kondo, Y
Kanzawa, T
Sawaya, R
Kondo, S
[J]. NATURE REVIEWS CANCER, 2005, 5 (09) : 726 - 734
[7] The role of autophagy during the early neonatal starvation period
Kuma, A
Hatano, M
Matsui, M
Yamamoto, A
Nakaya, H
Yoshimori, T
Ohsumi, Y
Tokuhisa, T
Mizushima, N
[J]. NATURE, 2004, 432 (7020) : 1032 - 1036
[8] Growth factor regulation of autophagy and cell survival in the absence of apoptosis
Lum, JJ
Bauer, DE
Kong, M
Harris, MH
Li, C
Lindsten, T
Thompson, CB
[J]. CELL, 2005, 120 (02) : 237 - 248
[9] Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is required for induction of autophagy during lumen formation in vitro
Mills, KR
Reginato, M
Debnath, J
Queenan, B
Brugge, JS
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (10) : 3438 - 3443
[10] Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy
Pattingre, S
Tassa, A
Qu, XP
Garuti, R
Liang, XH
Mizushima, N
Packer, M
Schneider, MD
Levine, B
[J]. CELL, 2005, 122 (06) : 927 - 939

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