Ovarian cycle-related changes of glial fibrillary acidic protein (GFAP) immunoreactivity in the rat interpeduncular nucleus

被引：15

作者：

Hajós, F

Halasy, K

Gerics, B

Szalay, F

Michaloudi, E

Papadopoulos, GC

机构：

[1] Univ Vet Sci Budapest, Dept Anat & Histol, H-1400 Budapest, Hungary

[2] Aristotle Univ, Fac Vet Med, Dept Anat & Histol, Thessaloniki, Greece

来源：

BRAIN RESEARCH | 2000年 / 862卷 / 1-2期

关键词：

astrocytes; GFAP; immunohistochemistry; midbrain; estrous cycle;

D O I：

10.1016/S0006-8993(00)02065-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The interpeduncular nucleus (IPN) of female rats was studied across the estrous cycle to observe whether the expression of the astroglial marker, glial fibrillary acidic protein (GFAP) reacts to hormonal changes in an area not belonging to the 'endocrine brain'. A marked reduction of immunoreactive GFAP was observed in estrus as compared to the immunoreactivities in met- and proestrus. This finding is consistent with earlier observations in the endocrine hypothalamus, but also proves that gonadal steroids influence astroglia in brain regions not involved in neuroendocrine regulation. Since cyclic fluctuations of synaptic numbers in the female have been described only for the endocrine hypothalamus, decrease of immunoreactive GFAP in the IPN during estrus may reflect a down-regulation of CFAP synthesis. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：43 / 48

页数：6

共 35 条

[1] SUBSTANCE-P IN THE INTERPEDUNCULAR NUCLEUS OF THE RAT - NORMAL-DISTRIBUTION AND THE EFFECTS OF DEAFFERENTATION [J].