High interstitial fluid pressure -: An obstacle in cancer therapy

被引:1695
作者
Heldin, CH
Rubin, K
Pietras, K
Östman, A
机构
[1] Ludwig Inst Canc Res, SE-75124 Uppsala, Sweden
[2] Uppsala Univ, BMC, Dept Med Biochem & Microbiol, SE-75123 Uppsala, Sweden
[3] Univ Calif San Francisco, San Francisco, CA 94143 USA
[4] Karolinska Inst, Dept Pathol Oncol, Canc Ctr Karolinska, SE-17176 Stockholm, Sweden
关键词
D O I
10.1038/nrc1456
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Many solid tumours show an increased interstitial fluid pressure (IFP), which forms a barrier to transcapillary transport. This barrier is an obstacle in tumour treatment, as it results in inefficient uptake of therapeutic agents. There are a number of factors that contribute to increased IFP in the tumour, such as vessel abnormalities, fibrosis and contraction of the interstitial matrix. Lowering the tumour IFP with specific signal-transduction antagonists might be a useful approach to improving anticancer drug efficacy.
引用
收藏
页码:806 / 813
页数:8
相关论文
共 76 条
[1]   Analysis of mural cell recruitment to tumor vessels [J].
Abramsson, A ;
Berlin, Ö ;
Papayan, H ;
Paulin, D ;
Shani, M ;
Betsholtz, C .
CIRCULATION, 2002, 105 (01) :112-117
[2]   Endothelial and nonendothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors [J].
Abramsson, A ;
Lindblom, P ;
Betsholtz, C .
JOURNAL OF CLINICAL INVESTIGATION, 2003, 112 (08) :1142-1151
[3]   Molecular mechanisms of lymphangiogenesis in health and disease [J].
Alitalo, K ;
Carmeliet, P .
CANCER CELL, 2002, 1 (03) :219-227
[4]   INTERSTITIAL-LYMPHATIC MECHANISMS IN THE CONTROL OF EXTRACELLULAR FLUID VOLUME [J].
AUKLAND, K ;
REED, RK .
PHYSIOLOGICAL REVIEWS, 1993, 73 (01) :1-78
[5]   Abnormalities of basement membrane on blood vessels and endothelial sprouts in tumors [J].
Baluk, P ;
Morikawa, S ;
Haskell, A ;
Mancuso, M ;
McDonald, DM .
AMERICAN JOURNAL OF PATHOLOGY, 2003, 163 (05) :1801-1815
[6]   Effect of PGE1, PGI2, and PGF2α analogs on collagen gel compaction in vitro and interstitial pressure in vivo [J].
Berg, A ;
Ekwall, AKH ;
Rubin, K ;
Stjernschantz, J ;
Reed, RK .
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 1998, 274 (02) :H663-H671
[7]   Cytochalasin D induces edema formation and lowering of interstitial fluid pressure in rat dermis [J].
Berg, A ;
Rubin, K ;
Reed, RK .
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2001, 281 (01) :H7-H13
[8]   Dietary effects of arachidonate-rich fungal oil and fish oil on murine hepatic and hippocampal gene expression [J].
Alvin Berger ;
David M Mutch ;
J Bruce German ;
Matthew A Roberts .
Lipids in Health and Disease, 1 (1)
[9]  
BOUCHER Y, 1990, CANCER RES, V50, P4478
[10]  
BOUCHER Y, 1991, CANCER RES, V51, P6691