Bone formation mediated by synergy-acting growth factors embedded in a polyelectrolyte multilayer film

被引：80

作者：

Dierich, Andree

Le Guen, Erell

Messaddeq, Nadia

Stoltz, Jean-Francois

Netter, Patrick

Schaaf, Pierre

Voegel, Jean-Claude

Benkirane-Jessel, Nadia

机构：

[1] Univ Strasbourg, Fac Chirurg Dent, INSERM, U595,Fac Med, F-67085 Strasbourg, France

[2] ULP, Coll France, CNRS, INSERM,Inst Clin Souris,IGBMC, Strasbourg, France

[3] Univ Nancy 1, CNRS, UMR 7561, Fac Med, F-54000 Nancy, France

[4] ULP, CNRS, Inst Charles Sadron, F-67083 Strasbourg, France

来源：

ADVANCED MATERIALS | 2007年 / 19卷 / 05期

关键词：

D O I：

10.1002/adma.200601271

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A bifunctionalized polyelectrolyte multilayer film (PEM film) that can drive embryonic stem cells to cartilage or bone differentiation is presented. A model system is constructed from a PEM film into which transforming growth factor P, and bone morphogenetic protein has been embedded. The synergy between both factors is required for the film to be bioactive. Osteogenesis in embryonic stem cells is induced by the film (see figure).

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页码：693 / +

页数：6

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