Biomarkers of oxidative damage and inflammation in Alzheimer's disease

被引：133

作者：

Galasko, Douglas ^{[1
]}

Montine, Thomas J. ^{[2
]}

机构：

[1] Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA

[2] Univ Washington, Div Neuropathol, Seattle, WA 98104 USA

来源：

BIOMARKERS IN MEDICINE | 2010年 / 4卷 / 01期

关键词：

Alzheimer's disease; biomarker; cytokines; F(2)-isoprostanes; oxidative stress; MILD COGNITIVE IMPAIRMENT; CEREBROSPINAL-FLUID S100B; GENOME-WIDE ASSOCIATION; RECEPTOR-TYPE-II; VASCULAR DEMENTIA; BIOCHEMICAL MARKERS; IDENTIFIES VARIANTS; PARKINSONS-DISEASE; LIPID-PEROXIDATION; INTRATHECAL LEVELS;

D O I：

10.2217/BMM.09.89

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Oxidative damage and inflammation are important features of the brain pathology of Alzheimer's disease (AD). oxidative damage can be found in membranes (lipid peroxidation), proteins (nitrosylation and other post-translational changes) and nucleic acids. Inflammatory changes include activation of microglia and astrocytes, with increased levels of proinflammatory cytokines. Not all of these changes are specific to AD, and occur in other neurodegenerative disorders. Both oxidative stress and inflammation are potential therapeutic targets in AD, and biomarkers could help to identify and monitor key pathways in patients with AD. This article summarizes progress in developing cerebrospinal fluid biomarkers related to oxidative stress and inflammation, problems and pitfalls related to systemic (blood- or urine-based) biomarkers in this area, and future research directions and applications.

引用

页码：27 / 36

页数：10

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