Influence of Helicobacter pylori infection on the phenotype of Crohn's disease

被引:15
作者
Püspök, A
Dejaco, C
Oberhuber, G
Waldhör, T
Hirschl, AM
Vogelsang, H
Gasche, C
机构
[1] AKH, Clin Internal Med 4, Dept Gastroenterol & Hepatol, A-1090 Vienna, Austria
[2] AKH, Dept Clin Pathol, Vienna, Austria
[3] Inst Tumorbiol & Canc Res, Vienna, Austria
[4] Univ Vienna, Dept Clin Microbiol, Vienna, Austria
关键词
D O I
10.1111/j.1572-0241.1999.01528.x
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
OBJECTIVE: Very little is known about the impact of Helicobacter pylori (H. pylori) infection on Crohn's disease. In this study we investigated a possible influence of H. pylori on the phenotype of Crohn's disease. METHODS: Patients with Crohn's disease who had gastric biopsy between 1990 and 1994 and a clinical follow-up in our outpatient clinic for at least 2 yr were included in the study. The mean number of flare-ups per year of follow-up, the mean numbers of intestinal resections per year of disease duration, and primary disease location were compared in H. pylori-positive and -negative patients. Various regression models were calculated to test the influence of H. pylori status on these parameters, correcting for smoking habits and disease duration. RESULTS: Of 131 patients, 50 (38.2%) were H. pylori positive and 62 (47.3%) were smokers. Due to a significant interaction between smoking habits and H. pylori infection, regression models were calculated separately for smokers and nonsmokers. Nonsmokers without H. pylori infection had more flare-ups than nonsmokers with H. pylori infection (0.77 [0.57-0.97] vs 0.29 [0.16-0.42]; p < 0.01; mean [95% confidence interval]). Tn contrast, nonsmokers without H. pylori infection had less intestinal resections than nonsmokers infected with H. pylori (0.08 [0.04-0.12] vs 0.11 [0.07-0.15]; p < 0.05). These differences were not significant for smokers (p < 0.41 and p < 0.07). There was a predominance of small bowel disease in H. pylori-positive patients, which did not reach statistical significance. CONCLUSIONS: Our data indicate that H. pylori influences the phenotype of Crohn's disease, especially in nonsmokers. (C) 1999 by Am. Coil. of Gastroenterology.
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页码:3239 / 3244
页数:6
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