Anion hopping of (and on) functional oligoarginines: from chloroform to cells

被引：49

作者：

Sakai, Naomi ^{[1
]}

Futaki, Shiroh

Matile, Stefan

机构：

[1] Univ Geneva, Dept Organ Chem, CH-1211 Geneva, Switzerland

[2] Kyoto Univ, Inst Chem Res, Kyoto 606, Japan

[3] JST, CREST, Kyoto, Japan

来源：

SOFT MATTER | 2006年 / 2卷 / 08期

关键词：

D O I：

10.1039/b606955j

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Rapid progress in the understanding of counteranions as either activators or inactivators of guanidinium-rich macromolecules is summarized. From phase transfer of polyarginine into chloroform to the cytosolic delivery of green-fluorescent proteins or apoptosis-inducing peptides with cell-penetrating peptides, counteranions emerge consistently as the origin of function. A unified view of this "demystified arginine magic" is proposed, focusing on the manipulation of the underlying anion hopping of and on these sticky molecular chameleons according to the principle of Le Chatelier.

引用

页码：636 / 641

页数：6

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