DD genotype of ACE gene is a risk factor for intracerebral hemorrhage

被引：64

作者：

Slowik, A

Turaj, W

Dziedzic, T

Haefele, A

Pera, J

Malecki, MT

Glodzik-Sobanska, L

Szermer, P

Figlewicz, DA

Szczudlik, A

机构：

[1] Jagiellonian Univ, Dept Neurol, Coll Med, PL-31503 Krakow, Poland

[2] Jagiellonian Univ, Dept Metab Dis, Coll Med, PL-31503 Krakow, Poland

[3] Univ Rochester, Dept Neurol, Rochester, NY 14627 USA

来源：

NEUROLOGY | 2004年 / 63卷 / 02期

关键词：

D O I：

10.1212/01.WNL.0000130200.12993.0C

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Genetic factors may play a role in susceptibility to stroke. The angiotensin converting enzyme ( ACE) gene is a candidate gene for two phenotypically different types of stroke affecting small perforating arteries: spontaneous intracerebral hemorrhage (SIH) and ischemic stroke due to small vessel disease (SVD). The authors report evidence that ACE gene DD homozygosity of the I/D polymorphism in intron 16 is an independent risk factor for SIH, and not for SVD stroke, in a Polish population.

引用

页码：359 / 361

页数：3

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