CD14 signalling in lipid rafts:: new ligands and co-receptors

被引：96

作者：

Schmitz, G ^{[1
]}

Orsó, E ^{[1
]}

机构：

[1] Univ Regensburg, Inst Clin Chem & Lab Med, D-93053 Regensburg, Germany

来源：

CURRENT OPINION IN LIPIDOLOGY | 2002年 / 13卷 / 05期

关键词：

CD14-dependent receptor cluster; raft-heterogeneity; LPS-mediated signalling; atherogenesis; innate immunity; mononuclear phagocytes;

D O I：

10.1097/00041433-200210000-00007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Purpose of review Lipid rafts on monocytes/macrophages provide a dynamic microenvironment for an integrated lipopolysaccharide receptor (CD14)-dependent clustering of a set of receptors involved in innate immunity and clearance of atherogenic lipoproteins. The purpose of this review is to summarize the recent advances in our understanding of CD14-dependent receptor clustering and its relevance in atherogenesis. Recent findings Upon binding of various ligands, CD14 as a multiligand pattern recognition receptor induces specific coassembly of additional receptors present on circulating monocytes. Summary The composition of the receptor cluster and thus the associated signalling pathways defines a ligand specific cellular response, linking endogenous and exogenous host defense to a common recognition platform in rafts.

引用

页码：513 / 521

页数：9

共 59 条

[1] TLR4 mutations are associated with endotoxin hyporesponsiveness in humans [J].

Arbour, NC ;

Lorenz, E ;

Schutte, BC ;

Zabner, J ;

Kline, JN ;

Jones, M ;

Frees, K ;

Watt, JL ;

Schwartz, DA .

NATURE GENETICS, 2000, 25 (02) :187-+

[2] Evidence for a role of phospholipid oxidation products in atherogenesis [J].

Berliner, JA ;

Subbanagounder, G ;

Leitinger, N ;

Watson, AD ;

Vora, D .

TRENDS IN CARDIOVASCULAR MEDICINE, 2001, 11 (3-4) :142-147

[3] Lipopolysaccharide complexed with soluble CD14 binds to normal human monocytes [J].

Blondin, C ;

Le Dur, A ;

Cholley, B ;

Caroff, M ;

Haeffner-Cavaillon, N .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1997, 27 (12) :3303-3309

[4] Protective immunity against atherosclerosis carried by B cells of hypercholesterolemic mice [J].

Caligiuri, G ;

Nicoletti, A ;

Poirier, B ;

Hansson, GK .

JOURNAL OF CLINICAL INVESTIGATION, 2002, 109 (06) :745-753

[5] Prominin:: A story of cholesterol, plasma membrane protrusions and human pathology [J].

Corbeil, D ;

Röper, K ;

Fargeas, CA ;

Joester, A ;

Huttner, WB .

TRAFFIC, 2001, 2 (02) :82-91

[6] Apolipoprotein AI and HDL3 inhibit spreading of primary human monocytes through a mechanism that involves cholesterol depletion and regulation of CDC42 [J].

Diederich, W ;

Orsó, E ;

Drobnik, W ;

Schmitz, G .

ATHEROSCLEROSIS, 2001, 159 (02) :313-324

[7] Inhibitory effect on arterial injury-induced neointimal formation by adoptive B-cell transfer in Rag-1 knockout mice [J].

Dimayuga, P ;

Cercek, B ;

Oguchi, S ;

Fredrikson, GN ;

Yano, J ;

Shah, PK ;

Jovinge, S ;

Nilsson, J .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2002, 22 (04) :644-649

[8] Apo Al/ABCA1-dependent and HDL3-mediated lipid efflux from compositionally distinct cholesterol-based microdomains [J].

Drobnik, W ;

Borsukova, H ;

Böttcher, A ;

Pfeiffer, A ;

Liebisch, G ;

Schütz, GJ ;

Schindler, H ;

Schmitz, G .

TRAFFIC, 2002, 3 (04) :268-278

[9] MD-2 enables toll-like receptor 2 (TLR2)-mediated responses to lipopolysaccharide and enhances TLR2-mediated responses to gram-positive and gram-negative bacteria and their cell wall components [J].

Dziarski, R ;

Wang, QL ;

Miyake, K ;

Kirschning, CJ ;

Gupta, D .

JOURNAL OF IMMUNOLOGY, 2001, 166 (03) :1938-1944

[10] Expression of toll-like receptors in human atherosclerotic lesions - A possible pathway for plaque activation [J].

Edfeldt, K ;

Swedenborg, J ;

Hansson, GK ;

Yan, ZQ .

CIRCULATION, 2002, 105 (10) :1158-1161

← 1 2 3 4 5 6 →