Bio-specific recognition and applications: from molecular to colloidal scales

被引:21
作者
Baudry, J
Bertrand, E
Lequeux, N
Bibette, J
机构
[1] ESPCI, Lab Colloides & Mat Divises, F-75231 Paris 05, France
[2] CNRS, UMR 7612, F-75231 Paris 05, France
关键词
D O I
10.1088/0953-8984/16/15/R02
中图分类号
O469 [凝聚态物理学];
学科分类号
070205 ;
摘要
Biomolecules have the well-known ability to build reversible complexes. Indeed, antigens and antibodies or adhesion molecules are able to recognize one another with a strong affinity and a very high specificity. This paper first reviews the various techniques and related results about binding and unbinding, at the scale of a unique ligand/receptor couple. One important biotechnological application arising from these recognition phenomena concerns immuno-diagnosis, which is essentially based on the formation of these specific complexes. We show how the physics of colloids associated with the growing scientific background concerning molecular recognition helps in rationalizing and inventing new diagnostic strategies. Finally the concept of colloidal self-assembling systems as biosensors is presented as directly impacting the most important questions related to molecular recognition and their biotechnological implications.
引用
收藏
页码:R469 / R480
页数:12
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