Mechanisms of Action of Phytochemicals from Medicinal Herbs in the Treatment of Alzheimer's Disease

被引：79

作者：

Kim, Mi Hye ^{[1
,2
]}

Kim, Sung-Hoon ^{[3
]}

Yang, Woong Mo ^{[1
,2
]}

机构：

[1] Kyung Hee Univ, Coll Korean Med, Seoul 130701, South Korea

[2] Kyung Hee Univ, Inst Korean Med, Seoul 130701, South Korea

[3] Kyung Hee Univ, Coll Korean Med, Canc Prevent Mat Dev Res Ctr, Seoul 130701, South Korea

来源：

PLANTA MEDICA | 2014年 / 80卷 / 15期

基金：

新加坡国家研究基金会;

关键词：

Alzheimer's disease; phytochemical; medicinal herbs; drug development; AMYLOID PRECURSOR PROTEIN; NF-KAPPA-B; GINSENOSIDE RG1; BETA-SECRETASE; A-BETA; COGNITIVE IMPAIRMENT; IN-VITRO; INFLAMMATORY RESPONSE; CURCUMIN PROTECTS; OXIDATIVE STRESS;

D O I：

10.1055/s-0034-1383038

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Alzheimer's disease is a chronic neurodegenerative disorder characterized by progressive dementia and deterioration of cognitive function. Although several drugs currently used for the treatment of Alzheimer's disease delay its onset and slow its progression, still there is no drug with profound disease-modifying effects. Studies aiming the treatment of this neurodegenerative disorder explore various disease mechanisms. Since antiquity, medicinal herbs have been used in traditional medicine. Recent studies suggest that the neurobiological effects of phytochemicals from medicinal herbs may contribute to clinical benefits in in vitro and in vivo models of Alzheimer's disease. This review focuses on five phytochemicals, berberine, curcumin, ginsenoside Rg1, puerarin, and silibinin, which have been mostly investigated to treat the development and progression of this neurodegenerative disorder.

引用

页码：1249 / 1258

页数：10

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