Segmental paralogy in the human genome: a large-scale triplication on 1p, 6p, and 21q

被引：15

作者：

Strippoli, P ^{[1
]}

D'Addabbo, P ^{[1
]}

Lenzi, L ^{[1
]}

Giannone, S ^{[1
]}

Canaider, S ^{[1
]}

Casadei, R ^{[1
]}

Vitale, L ^{[1
]}

Carinci, P ^{[1
]}

Zannotti, N ^{[1
]}

机构：

[1] Univ Bologna, Inst Histol & Gen Embryol, Res Ctr Mol Genet Fdn CARISBO, I-40126 Bologna, Italy

来源：

MAMMALIAN GENOME | 2002年 / 13卷 / 08期

关键词：

D O I：

10.1007/s00335-001-2157-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Few cases of large-scale segmental paralogy have been reported in the human genome. We have identified large (similar to500 kb) segment on human chromosome (HC) 21 (21q22) that is triplicated on HC 1 (1p35) and HC 6 (6p12-21). We also identified a new member of CLIC (Chloride Intracellular Channel) family oil 21q. namely CLIC6. All three segments appear to include three functional members of three different gene families: DSCR1-like (Down Syndrome Candidate Region 1-like). CLIC, and AML/Runt (Acute Myeloid Leukemia Runt). Molecular evolution analysis shows a common evolutionary origin for the triplicated regions. This finding of a further large-scale genomic triplication that went undetected at previously systematic automated searches provides a new model for acne divergence study and underlines the need for new tools to effectively detect inter-chromosomal similarity. An algorithm to overcome current limitations is proposed.

引用

页码：456 / 462

页数：7

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