Mixed pathologies and neural reserve: Implications of complexity for Alzheimer disease drug discovery

被引:51
作者
Bennett, David A. [1 ]
机构
[1] Rush Univ, Med Ctr, Rush Alzheimers Dis Ctr, Chicago, IL 60612 USA
关键词
COGNITIVE DECLINE; DEMENTIA; PREVALENCE; EDUCATION; BRAIN; NEUROPATHOLOGY; NUN; AGE;
D O I
10.1371/journal.pmed.1002256
中图分类号
R5 [内科学];
学科分类号
100201 [内科学];
摘要
[No abstract available]
引用
收藏
页数:4
相关论文
共 26 条
[1]
Relation of cerebral vessel disease to Alzheimer's disease dementia and cognitive function in elderly people: a cross-sectional study [J].
Arvanitakis, Zoe ;
Capuano, Ana W. ;
Leurgans, Sue E. ;
Bennett, David A. ;
Schneider, Julie A. .
LANCET NEUROLOGY, 2016, 15 (09) :934-943
[2]
Much of Late Life Cognitive Decline Is Not due to Common Neurodegenerative Pathologies [J].
Boyle, Patricia A. ;
Wilson, Robert S. ;
Yu, Lei ;
Barr, Alasdair M. ;
Honer, William G. ;
Schneider, Julie A. ;
Bennett, David A. .
ANNALS OF NEUROLOGY, 2013, 74 (03) :478-489
[3]
Education, the brain and dementia: neuroprotection or compensation? [J].
Brayne, Carol ;
Ince, Paul G. ;
Keage, Hannah A. D. ;
McKeith, Ian G. ;
Matthews, Fiona E. ;
Polvikoski, Tuomo ;
Sulkava, Raimo .
BRAIN, 2010, 133 :2210-2216
[4]
Impact of interventions to reduce Alzheimer's disease pathology on the prevalence of dementia in the oldest-old [J].
Brookmeyer, Ron ;
Kawas, Claudia H. ;
Abdallah, Nada ;
Paganini-Hill, Annlia ;
Kim, Ronald C. ;
Corrada, Maria M. .
ALZHEIMERS & DEMENTIA, 2016, 12 (03) :225-232
[5]
Higher brain BDNF gene expression is associated with slower cognitive decline in older adults [J].
Buchman, Aron S. ;
Yu, Lei ;
Boyle, Patricia A. ;
Schneider, Julie A. ;
De Jager, Philip L. ;
Bennett, David A. .
NEUROLOGY, 2016, 86 (08) :735-741
[6]
Alzheimer's disease drug-development pipeline: few candidates, frequent failures [J].
Cummings, Jeffrey L. ;
Morstorf, Travis ;
Zhong, Kate .
ALZHEIMERS RESEARCH & THERAPY, 2014, 6 (04)
[7]
An autopsy-verified study of the effect of education on degenerative dementia [J].
Del Ser, T ;
Hachinski, V ;
Merskey, H ;
Munoz, DG .
BRAIN, 1999, 122 :2309-2319
[8]
Dodge HH, 2016, ALZHEIMERS DEMENT
[9]
Very low levels of education and cognitive reserve A clinicopathologic study [J].
Farfel, Jose Marcelo ;
Nitrini, Ricardo ;
Suemoto, Claudia Kimie ;
Grinberg, Lea Tenenholz ;
Lucena Ferretti, Renata Eloah ;
Paraizo Leite, Renata Elaine ;
Tampellini, Edilaine ;
Lima, Luzia ;
Farias, Daniela Souza ;
Neves, Ricardo Caires ;
Rodriguez, Roberta Diehl ;
Menezes, Paulo Rossi ;
Fregni, Felipe ;
Bennett, David A. ;
Pasqualucci, Carlos Augusto ;
Jacob Filho, Wilson .
NEUROLOGY, 2013, 81 (07) :650-657
[10]
Prevalence of dementia subtypes in a developing country: a clinicopathological study [J].
Grinberg, Lea T. ;
Nitrini, Ricardo ;
Suemoto, Claudia K. ;
de Lucena Ferretti-Rebustini, Renata Eloah ;
Leite, Renata E. P. ;
Farfel, Jose Marcelo ;
Santos, Erika ;
Guilhermino de Andrade, Mara Patricia ;
Di Lorenzo Alho, Ana Tereza ;
Lima, Maria do Carmo ;
Oliveira, Katia C. ;
Tampellini, Edilaine ;
Polichiso, Livia ;
Santos, Glaucia B. ;
Rodriguez, Roberta Diehl ;
Ueda, Kenji ;
Pasqualucci, Carlos A. ;
Jacob-Filho, Wilson .
CLINICS, 2013, 68 (08) :1140-1145