The ADAM gene family - surface proteins with adhesion and protease activity

被引：492

作者：

Primakoff, P ^{[1
]}

Myles, DG

机构：

[1] Univ Calif Davis, Sch Med, Dept Cell Biol & Anat, Davis, CA 95616 USA

[2] Univ Calif Davis, Sect Mol & Cellular Biol, Davis, CA 95616 USA

来源：

TRENDS IN GENETICS | 2000年 / 16卷 / 02期

关键词：

D O I：

10.1016/S0168-9525(99)01926-5

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

An ADAM is a transmembrane protein that contains a disintegrin and metalloprotease domain and, therefore, it potentially has both cell adhesion and protease activities. Currently, the ADAM gene family has 29 members, although the function of most ADAM gene products is unknown. We discuss the ADAM gene products with known functions that act in a highly diverse set of biological processes, including fertilization, neurogenesis, myogenesis, embryonic TGF-alpha release and the inflammatory response.

引用

页码：83 / 87

页数：5

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