Nef enhances human immunodeficiency virus type 1 infectivity and replication independently of viral coreceptor tropism

被引：85

作者：

Papkalla, A

Münch, J

Otto, C

Kirchhoff, F

机构：

[1] Univ Ulm, Dept Virol, D-89081 Ulm, Germany

[2] Univ Erlangen Nurnberg, Inst Clin & Mol Virol, D-91054 Erlangen, Germany

来源：

JOURNAL OF VIROLOGY | 2002年 / 76卷 / 16期

关键词：

D O I：

10.1128/JVI.76.16.8455-8459.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We investigated the infectivities and replicative capacities of a large panel of variants of the molecular human immunodeficiency virus type 1 (HIV-1) NL4-3 clone that differ exclusively in the V3 region of the viral envelope glycoprotein and the nef gene. Our results demonstrate that Nef enhances virion infectivity and HIV-1 replication independently of the viral coreceptor tropism.

引用

收藏

页码：8455 / 8459

页数：5

相关论文

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