Chitosan-inducing hemorrhagic pneumonia in dogs

被引：32

作者：

Minami, S ^{[1
]}

OhOka, M ^{[1
]}

Okamoto, Y ^{[1
]}

Miyatake, K ^{[1
]}

Matsuhashi, A ^{[1
]}

Shigemasa, Y ^{[1
]}

Fukumoto, Y ^{[1
]}

机构：

[1] TOTTORI UNIV,FAC ENGN,DEPT MAT SCI,TOTTORI 680,JAPAN

来源：

CARBOHYDRATE POLYMERS | 1996年 / 29卷 / 03期

关键词：

D O I：

10.1016/0144-8617(95)00157-3

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Various amounts of chitosan (10-200 mg/kg) were administered subcutaneously to dogs. Anorexia and mortality were observed in dogs given doses above 50 mg/kg, and above 150 mg/kg, respectively. In hematologic findings leukocytosis and increasing of serum LDH(2) and LDH(3) isoenzymes were characteristic. From the findings of autopsy, severe hemorrhagic pneumonia was observed in all dead dogs. Chitosan causes lethal pneumonia to dogs. Copyright (C) 1996 Elsevier Science Limited.

引用

页码：241 / 246

页数：6

共 25 条

[1]

Arai K., 1968, B TOKAI REGIONAL FIS, V56, P89

[2]

BALLIN HM, 1960, P SOC EXP BIOL MED, V103, P93, DOI 10.3181/00379727-103-25423

[3] ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE-1 - AN INDUCIBLE RECEPTOR FOR NEUTROPHILS RELATED TO COMPLEMENT REGULATORY PROTEINS AND LECTINS [J].

BEVILACQUA, MP ;

STENGELIN, S ;

GIMBRONE, MA ;

SEED, B .

SCIENCE, 1989, 243 (4895) :1160-1165

[4]

HEAVNER JE, 1986, AM J VET RES, V47, P1772

[5]

HONDA M, 1982, AM J PATHOL, V108, P171

[6]

JORDAN JE, 1977, AM J VET RES, V38, P509

[7]

JUTILA MA, 1989, J IMMUNOL, V143, P3318

[8]

Kikuta Y., 1987, Journal of the Japan Veterinary Medical Association, V40, P26

[9] NEUTROPHIL MAC-1 AND MEL-14 ADHESION PROTEINS INVERSELY REGULATED BY CHEMOTACTIC FACTORS [J].

KISHIMOTO, TK ;

JUTILA, MA ;

BERG, EL ;

BUTCHER, EC .

SCIENCE, 1989, 245 (4923) :1238-1241

[10]

KITAMURA N, 1985, J VET MED, V763, P96

← 1 2 3 →