Enantioselective addition of amines to ketenes catalyzed by a planar-chiral derivative of PPY: Possible intervention of chiral Bronsted-acid catalysis

被引：116

作者：

Hodous, BL ^{[1
]}

Fu, GC ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2002年 / 124卷 / 34期

关键词：

D O I：

10.1021/ja027466x

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first method for the catalytic enantioselective addition of amines (specifically, pyrroles) to ketenes has been developed, and it has been demonstrated that the resulting acylpyrroles can be transformed into a broad spectrum of useful derivatives. On the basis of mechanistic studies, it is suggested that the planar-chiral catalyst plays an unanticipated role in this process as a chiral Brønsted acid. Copyright © 2002 American Chemical Society.

引用

页码：10006 / 10007

页数：2

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