Developmental toxic effects of chronic exposure to high doses of iodine in the mouse

被引：26

作者：

Yang, Xue F. ^{[1
]}

Xu, Han ^{[1
]}

Hou, Xiao H. ^{[1
]}

Guo, Huai L. ^{[1
]}

Hao, Li P. ^{[1
]}

Yao, Ping ^{[1
]}

Liu, Lie G. ^{[1
]}

Sun, Xiu F. ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Nutr & Food Hyg, Sch Publ Hlth, Wuhan 430030, Peoples R China

来源：

REPRODUCTIVE TOXICOLOGY | 2006年 / 22卷 / 04期

基金：

中国国家自然科学基金;

关键词：

high doses of iodine; thyroid hormone; developmental toxicity; mouse;

D O I：

10.1016/j.reprotox.2006.05.010

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Chronic exposure to high doses of iodine induces thyroid dysfunction, but effects of chronic exposure to high amounts of iodine on pregnancy and fetal outcome are uncertain. In the present study, Balb/C mice were given different doses of iodine at the levels of 0 (sterile water), 1500, 3000, 6000, 12,000 and 24,000 mu g/L in drinking water for 4 months, then were mated and the developmental toxicity and teratogenicity were evaluated. An obvious colloid goiter was observed, and serum total thyroxine (TT4) levels increased and serum total triiodothyronine (TT3) levels decreased significantly in dams when iodine dose reached 3000 mu g/L. Maternal effect was evident by the reduction of average daily food consumption in higher doses of iodine groups. Embryotoxicity and teratogenicity were mainly indicated by the reduced body weight in female fetuses, the decreased number of live fetuses, and the increased incidence of resorptions, and especially skeletal variations. These results suggest that exposure to maternally toxic doses of iodine may have a potential developmental toxic effect. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：725 / 730

页数：6

共 36 条

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