Investigation of age-related variations in biogenic magnetite levels in the human hippocampus

被引：41

作者：

Dobson, J ^{[1
]}

机构：

[1] Univ Keele, Dept Biomed Engn & Med Phys, Ctr Sci & Technol Med, Stoke On Trent ST4 7QB, Staffs, England

来源：

EXPERIMENTAL BRAIN RESEARCH | 2002年 / 144卷 / 01期

关键词：

magnetite; hippocampus; epilepsy; iron oxide; neurodegenerative disease;

D O I：

10.1007/s00221-002-1066-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The magnetic properties of human hippocampal tissue from 23 subjects (15 epilepsy patients and eight cadavers with no neuropathology) were analysed and tissue concentrations of magnetic material were calculated. The biogenic iron oxide magnetite (Fe3O4) is the dominant source of magnetisation in the tissue. Analysis of the group as a whole revealed no significant trend towards either increasing or decreasing magnetite concentration with age. Separate analysis of male and female subjects, however, reveals a trend towards increasing magnetite concentration with age in males. This trend is not seen in females and may have implications for iron metabolism and neurological disorders associated with disruptions in normal iron homeostasis.

引用

页码：122 / 126

页数：5

共 27 条

[1] T2 VALUES IN THE HUMAN-BRAIN - COMPARISON WITH QUANTITATIVE ASSAYS OF IRON AND FERRITIN [J].