Current View on the Mechanism of Action of Perifosine in Cancer

被引：44

作者：

Fensterle, Joachim ^{[1
]}

Aicher, Babette ^{[1
]}

Seipelt, Irene ^{[1
]}

Teifel, Michael ^{[1
]}

Engel, Juergen ^{[1
]}

机构：

[1] Aeterna Zentaris, D-60314 Frankfurt, Germany

来源：

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY | 2014年 / 14卷 / 04期

关键词：

APL miltefosine; cancer; perifosine; AKT INHIBITOR PERIFOSINE; MYELOGENOUS LEUKEMIA-CELLS; MULTIPLE-MYELOMA CELLS; LIPID RAFTS; IN-VITRO; ALKYLPHOSPHOLIPID PERIFOSINE; ANTITUMOR-ACTIVITY; ANTICANCER ALKYLPHOSPHOLIPIDS; KINASE INHIBITORS; DEATH RECEPTORS;

D O I：

10.2174/1871520614666140309225912

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Perifosine treatment exhibits a complex molecular response including the inhibition of Akt or the induction of apoptosis via clustering of death receptors in lipid rafts. However, the molecular response can vary between different tumor entities and the contribution of each target pathway to the activity of Perifosine might be distinct depending on the tumor entity or the agent combined with Perifosine. In this review we discuss the current view on the mechanism of action of perifosine in cancer and the contribution of the molecular targets of Perifosine to its activity.

引用

收藏

页码：629 / 635

页数：7

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