Prognostic Value of High-Sensitivity C-Reactive Protein in Heart Failure: A Systematic Review

被引:112
作者
Araujo, Jose Paulo [1 ]
Lourenco, Patricia [1 ]
Azevedo, Ana [1 ,2 ]
Frioes, Fernando [1 ]
Rocha-Goncalves, Francisco [1 ]
Ferreira, Antonio [1 ]
Bettencourt, Paulo [1 ]
机构
[1] Hosp Sao Joao, Heart Failure Clin, Med Interna Serv, Unidade I&D Cardiovasc Porto, P-4202451 Oporto, Portugal
[2] Univ Porto, Serv Higiene & Epidemiol, P-4100 Oporto, Portugal
关键词
Heart failure; high-sensitivity C-reactive protein; inflammatory activation; myocardial infarction; prognosis; ACUTE MYOCARDIAL-INFARCTION; ACUTE CORONARY SYNDROMES; TUMOR-NECROSIS-FACTOR; LONG-TERM MORTALITY; ACUTE-PHASE RESPONSE; UNSTABLE ANGINA; DILATED CARDIOMYOPATHY; NATRIURETIC PEPTIDE; CARDIOVASCULAR-DISEASE; INDEPENDENT PREDICTOR;
D O I
10.1016/j.cardfail.2008.10.030
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Several studies have suggested that high-sensitivity C-reactive protein (hsCRP) is a strong independent predictor of acute myocardial infarction and cardiovascular death. In the specific heart failure (HF) context, a low-grade inflammatory state can contribute to HF progression. Aims: To perform a systematic review on the current knowledge about low-grade inflammation, as assessed by hsCRP, in the prediction of HF in general and in high-risk populations as well as its prognostic value in established HF. Methods: We used a computerized literature search in the Medline database using the following key words: C-Reactive Protein, Heart Failure, Cardiomyopathy, Cardiac Failure, Prognosis, and Death. Articles were selected if they had measurements of hsCRP in different patient samples and reference to outcomes in terms of morbidity and mortality. Results: hsCRP is associated with incident HF in general and high-risk populations and provides prognostic information in HF patients. In almost all studies, the association of hsCRP with clinical events was independent of other baseline variables known to influence morbidity and mortality. Very different cutoffs have been proposed in each context across studies. Conclusions: The prognostic power of hsCRP, whether we consider incident HF or adverse outcomes in established HF, is consistent in different patient populations. (J Cardiac Fail 2009:15:256-266)
引用
收藏
页码:256 / 266
页数:11
相关论文
共 86 条
[1]   C-reactive protein as a predictor of improvement and readmission in heart failure [J].
Alonso-Martínez, JL ;
Llorente-Diez, B ;
Echegaray-Agara, M ;
Olaz-Preciado, F ;
Urbieta-Echezarreta, M ;
González-Arencibia, C .
EUROPEAN JOURNAL OF HEART FAILURE, 2002, 4 (03) :331-336
[2]   Correlations of high-sensitivity C-reactive protein and atherosclerosis in Japanese type 2 diabetic patients [J].
Anan, Futoshi ;
Masaki, Takayuki ;
Umeno, Yoshikazu ;
Iwao, Tetsu ;
Yonemochi, Hidetoshi ;
Eshima, Nobuoki ;
Saikawa, Tetsunori ;
Yoshimatsu, Hironobu .
EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2007, 157 (03) :311-317
[3]   C-reactive protein in heart failure - Prognostic value and the effect of valsartan [J].
Anand, IS ;
Latini, R ;
Florea, VG ;
Kuskowski, MA ;
Rector, T ;
Masson, S ;
Signorini, S ;
Mocarelli, P ;
Hester, A ;
Glazer, R ;
Cohn, JN .
CIRCULATION, 2005, 112 (10) :1428-1434
[4]   Inflammatory mediators in chronic heart failure: An overview [J].
Anker, SD ;
von Haehling, S .
HEART, 2004, 90 (04) :464-470
[5]   Role of C-reactive protein in cardiovascular disease [J].
Backes, JM ;
Howard, PA ;
Moriarty, PM .
ANNALS OF PHARMACOTHERAPY, 2004, 38 (01) :110-118
[6]   Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins [J].
Baigent, C ;
Keech, A ;
Kearney, PM ;
Blackwell, L ;
Buck, G ;
Pollicino, C ;
Kirby, A ;
Sourjina, T ;
Peto, R ;
Collins, R ;
Simes, J .
LANCET, 2005, 366 (9493) :1267-1278
[7]   C-Reactive protein in acute myocardial infarction: Association with heart failure [J].
Berton, G ;
Cordiano, R ;
Palmieri, R ;
Pianca, S ;
Pagliara, V ;
Palatini, P .
AMERICAN HEART JOURNAL, 2003, 145 (06) :1094-+
[8]   Elevated levels of interleukin-6 in unstable angina [J].
Biasucci, LM ;
Vitelli, A ;
Liuzzo, G ;
Altamura, S ;
Caligiuri, G ;
Monaco, C ;
Rebuzzi, AG ;
Ciliberto, G ;
Maseri, A .
CIRCULATION, 1996, 94 (05) :874-877
[9]   Pathophysiologically relevant concentrations of tumor necrosis factor-α promote progressive left ventricular dysfunction and remodeling in rats [J].
Bozkurt, B ;
Kribbs, SB ;
Clubb, FJ ;
Michael, LH ;
Didenko, VV ;
Hornsby, PJ ;
Seta, Y ;
Oral, H ;
Spinale, FG ;
Mann, DL .
CIRCULATION, 1998, 97 (14) :1382-1391
[10]   C-reactive protein and heart failure after myocardial infarction in the community [J].
Bursi, Francesca ;
Weston, Susan A. ;
Killian, Jill M. ;
Gabriel, Sherine E. ;
Jacobsen, Steven J. ;
Roger, Veronique L. .
AMERICAN JOURNAL OF MEDICINE, 2007, 120 (07) :616-622