Impact of MCP-1 in Atherosclerosis

被引：259

作者：

Lin, Juntang ^{[1
,3
]}

Kakkar, Vijay ^{[2
]}

Lu, Xinjie ^{[1
,2
]}

机构：

[1] Xinxiang Med Univ, Coll Life Sci & Technol, Xinxiang 453003, Peoples R China

[2] Thrombosis Res Inst, Mary & Garry Weston Mol Immunol Lab, London SW3 6LR, England

[3] Univ Jena, Sch Med, Inst Anat 1, D-07743 Jena, Germany

来源：

CURRENT PHARMACEUTICAL DESIGN | 2014年 / 20卷 / 28期

基金：

中国国家自然科学基金;

关键词：

MCP-1; CCL2; CCLR2; atherosclerosis and chemokine; MONOCYTE CHEMOATTRACTANT PROTEIN-1; ENDOPLASMIC-RETICULUM STRESS; LOW-DENSITY-LIPOPROTEIN; SMOOTH-MUSCLE-CELLS; COLLATERAL ARTERY GROWTH; HUMAN ENDOTHELIAL-CELLS; CC-CHEMOKINE; IN-VITRO; GLYCOSAMINOGLYCAN BINDING; TRANSCRIPTION FACTOR;

D O I：

10.2174/1381612820666140522115801

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Monocyte chemotactic protein-1 (MCP-1) (also referred to as chemokine (C-C motif) ligand 2 (CCL2) is expressed by mainly inflammatory cells and endothelial cells. The expression level is upregulated after proinflammatory stimuli and tissue injury which are associated with atherosclerotic lesion. Atherosclerosis is a progressive disease starting with accumulation of lipids, lipoproteins, and immune cells in the arterial wall. MCP-1 has been reported to play an important role in the pathogenesis of atherosclerosis and considerable evidence supports that the monocyte containing MCPs and macrophage influences the growth of other cell types within the atherosclerotic lesion. This review will focus on the general structure features of MCP-1 and its role in atherosclerosis.

引用

页码：4580 / 4588

页数：9

共 155 条

[1]

Monocyte chemoattractant protein-1 accelerates atherosclerosis in apolipoprotein E-deficient mice [J].