Postmenopausal hormone replacement therapy: Effects on normal mammary gland in humans and in a mouse postmenopausal model

被引：40

作者：

Haslam, SZ

Osuch, JR

Raafat, AM

Hofseth, LJ

机构：

[1] Michigan State Univ, Dept Physiol, E Lansing, MI 48824 USA

[2] Michigan State Univ, Dept Surg, E Lansing, MI 48824 USA

[3] NCI, Lab Pathophysiol, NIH, Bethesda, MD 20892 USA

[4] NCI, Div Basic Sci, Human Carcinogenesis Lab, NIH, Bethesda, MD 20892 USA

来源：

JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA | 2002年 / 7卷 / 01期

关键词：

menopause; hormone replacement therapy; estrogen; progestin; breast cancer;

D O I：

10.1023/A:1015726608146

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Endogenous estrogen exposure has long been implicated in the causation of breast cancer through a mechanism of epithelial cell proliferation. Whether estrogen, progesterone, or both exhibit mitogenic activity and promote carcinogenesis in the human breast has been the subject of considerable debate. The purpose of this review article is to examine the evidence for the effects of hormone replacement therapy in its various forms on the biology of the postmenopausal breast both in humans and in an animal model, and to identify the gaps in knowledge that research will need to address to further understand this complex issue.

引用

页码：93 / 105

页数：13

共 81 条

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