Addition of a macrolide to a β-lactam in bacteremic pneumococcal pneumonia

被引:44
作者
Dwyer, R. [1 ]
Ortqvist, A.
Aufwerber, E.
Henriques Normark, B.
Marrie, T. J.
Mufson, M. A.
Torres, A.
Woodhead, M. A.
Alenius, M.
Kalin, M.
机构
[1] Karolinska Univ Hosp, Dept Med, Infect Dis Unit, S-14186 Huddinge, Sweden
[2] Swedish Inst Infect Dis Control, Dept Mol Epidemiol & Biotechnol, Stockholm, Sweden
[3] 2J2 00 Walter C Mackenzie Hlth Sci Ctr, Edmonton, AB 6 27, Canada
[4] Marshall Univ, John C Edwards Sch Med, Dept Med, Huntington, WV 25701 USA
[5] Hosp Clin Barcelona, Inst Clin Pneumol & Cirurg Torac, E-08036 Barcelona, Spain
[6] Manchester Royal Infirm, Dept Resp Med, Manchester M13 9WL, Lancs, England
关键词
D O I
10.1007/s10096-006-0183-2
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
In the study presented here, data collected prospectively from 340 adult patients hospitalised in five countries with bacteremic pneumococcal CAP and treated with a beta-lactam +/- a macrolide were analysed retrospectively to evaluate the efficacy of this antimicrobial combination. Univariate and multivariate analyses revealed no significant effect on case fatality rate when a macrolide/beta-lactam regimen was used as initial therapy. Results were not affected by severity of illness, or by excluding patients who died within 2 days of admission. Identified predictors of death in a multivariate regression model were age > 65 years (OR=2.6), two or more lung lobes affected (OR=2.2), and severity of disease as estimated using the acute physiology score (APS)> 8.
引用
收藏
页码:518 / 521
页数:4
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