Causes of early-onset type 1 diabetes: toward data-driven environmental approaches

被引：30

作者：

Bougneres, Pierre ^{[1
,2
]}

Valleron, Alain-Jacques ^{[3
,4
]}

机构：

[1] Univ Paris 05, Hop St Vincent de Paul, INSERM, Dept Pediat Endocrinol, F-75014 Paris, France

[2] Univ Paris 05, Hop St Vincent de Paul, INSERM, U561, F-75014 Paris, France

[3] Univ Paris 06, Hop St Antoine, INSERM, Unite Sante Publ, F-75012 Paris, France

[4] Univ Paris 06, Hop St Antoine, INSERM, U707, F-75012 Paris, France

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2008年 / 205卷 / 13期

关键词：

D O I：

10.1084/jem.20082622

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A new study reveals distinctive metabolic changes that precede the development of type 1 diabetes (T1D), tossing a stone into the quiet waters of T1D immunology and genetics. The causes of these metabolic changes and their relationship to autoimmunity and beta cell destruction are not yet known, but the identification of a metabolic phenotype linked to susceptibility to type I diabetes may help pave the way to a new era of investigation of T1D causality.

引用

收藏

页码：2953 / 2957

页数：5

相关论文

共 34 条

[1] Mechanisms of disease: The effect of infections on susceptibility to autoimmune and allergic diseases [J].

Bach, JF .

NEW ENGLAND JOURNAL OF MEDICINE, 2002, 347 (12) :911-920

[2] Insulin secretory responses and phospholipid composition of pancreatic islets from mice that do not express Group VIA phospholipase A2 and effects of metabolic stress on glucose homeostasis [J].

Bao, Shunzhong ;

Song, Haowei ;

Wohltmann, Mary ;

Ramanadham, Sasanka ;

Jin, Wu ;

Bohrer, Alan ;

Turk, John .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (30) :20958-20973

[3] HISTOCOMPATIBILITY-LINKED IMMUNE-RESPONSE GENES [J].

BENACERR.B ;

MCDEVITT, HO .

SCIENCE, 1972, 175 (4019) :273-&

[4] Consensus meeting: monosodium glutamate - an update [J].

Beyreuther, K. ;

Biesalski, H. K. ;

Fernstrom, J. D. ;

Grimm, P. ;

Hammes, W. P. ;

Heinemann, U. ;

Kempski, O. ;

Stehle, P. ;

Steinhart, H. ;

Walker, R. .

EUROPEAN JOURNAL OF CLINICAL NUTRITION, 2007, 61 (03) :304-313

[5] An integrated epigenetic and genetic approach to common human disease [J].

Bjornsson, HT ;

Fallin, MD ;

Feinberg, AP .

TRENDS IN GENETICS, 2004, 20 (08) :350-358

[6]

BOTTAZZO GF, 1974, LANCET, V2, P1280

[7] The spread of obesity in a large social network over 32 years [J].

Christakis, Nicholas A. ;

Fowler, James H. .

NEW ENGLAND JOURNAL OF MEDICINE, 2007, 357 (04) :370-379

[8] GLUTAMINE AND GLUTAMATE KINETICS IN HUMANS [J].

DARMAUN, D ;

MATTHEWS, DE ;

BIER, DM .

AMERICAN JOURNAL OF PHYSIOLOGY, 1986, 251 (01) :E117-E126

[9] Mendelian randomization: can genetic epidemiology help redress the failures of observational epidemiology? [J].

Ebrahim, Shah ;

Smith, George Davey .

HUMAN GENETICS, 2008, 123 (01) :15-33

[10] Diversity of the human intestinal microbial flora [J].

Eckburg, PB ;

Bik, EM ;

Bernstein, CN ;

Purdom, E ;

Dethlefsen, L ;

Sargent, M ;

Gill, SR ;

Nelson, KE ;

Relman, DA .

SCIENCE, 2005, 308 (5728) :1635-1638

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