Role of CCR2 in inflammatory conditions of the central nervous system

被引：137

作者：

Chu, Hannah X. ^{[1
]}

Arumugam, Thiruma V. ^{[2
]}

Gelderblom, Mathias ^{[3
]}

Magnus, Tim ^{[3
]}

Drunnnnond, Grant R. ^{[1
,4
]}

Sobey, Christopher G. ^{[1
,4
]}

机构：

[1] Monash Univ, Dept Pharmacol, Vasc Biol & Immunopharmacol Grp, Clayton, Vic 3800, Australia

[2] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Physiol, Singapore 117595, Singapore

[3] Univ Med Ctr Hamburg Eppendorf, Dept Neurol, Hamburg, Germany

[4] Monash Univ, Southern Clin Sch, Dept Surg, Clayton, Vic 3800, Australia

来源：

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 2014年 / 34卷 / 09期

关键词：

chemokine receptor CC2; CNS inflammation; ischemic stroke; monocytes; multiple sclerosis; MONOCYTE CHEMOATTRACTANT PROTEIN-1; CHEMOKINE RECEPTOR 2; TRANSGENIC MOUSE MODEL; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; FOCAL CEREBRAL-ISCHEMIA; BLOOD-BRAIN-BARRIER; COGNITIVE IMPAIRMENTS; AMYLOID PATHOLOGY; MICE DEFICIENT; T-LYMPHOCYTES;

D O I：

10.1038/jcbfm.2014.120

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

CC chemokine receptor 2 (CCR2) plays important roles in extravasation and transmigration of monocytes under inflammatory conditions. CCR2 and its ligands have been extensively studied in a range of inflammatory diseases in the central nervous system (CNS), including multiple sclerosis, Alzheimer's disease and ischemic stroke. This brief review summarizes our current understanding of the physiologic and pathologic roles of CCR2, focusing on its involvement in CNS inflammatory diseases. There appears to be a rationale for exploring therapies involving CCR2 inhibition in multiple sclerosis and ischemic stroke, but there is also evidence for immunomodulatory and protective effects of CCR2 activity during CNS inflammation. The critical balance between protective and detrimental roles of CCR2-dependent recruitment of leukocytes must therefore be carefully examined to guide safe and effective development of any therapies involving CCR2 modulation.

引用

页码：1425 / 1429

页数：5

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