14-3-3 Proteins and photoneuroendocrine transduction: role in controlling the daily rhythm in melatonin

被引:40
作者
Klein, DC [1 ]
Ganguly, S
Coon, S
Weller, JL
Obsil, T
Hickman, A
Dyda, F
机构
[1] NICHHD, Dev Neurobiol Lab, Sect Neuroendocrinol, NIH, Bethesda, MD 20892 USA
[2] NIDDK, Mol Biol Lab, NIH, Bethesda, MD 20892 USA
关键词
cAMP-dependent protein kinase; N-acetyltransferase; pineal;
D O I
10.1042/bst0300365
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
This paper describes the role 14-3-3 proteins play in vertebrate photoneuroendocrine transduction. 14-3-3 proteins form a complex with arylalkyl-amine N-acetyltransferase (AANAT), the enzyme which turns melatonin production on during the day and off at night. Complex formation is triggered at night by cAMP-dependent phosphorylation of the enzyme, and results in activation and protection against proteolysis. This enhances melatonin production > 10-fold. Light exposure results in dephosphorylation of the enzyme and disassociation from 14-3-3, leading to destruction and a rapid drop in melatonin production and release and circulating levels.
引用
收藏
页码:365 / 373
页数:9
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