Human Marginal Zone B Cells

被引：295

作者：

Weill, Jean-Claude ^{[1
]}

Weller, Sandra ^{[1
]}

Reynaud, Claude-Agnes ^{[1
]}

机构：

[1] Univ Paris 05, INSERM U783, Fac Med, F-75730 Paris 15, France

来源：

ANNUAL REVIEW OF IMMUNOLOGY | 2009年 / 27卷

关键词：

IgM memory; somatic hypermutation; hyper-IgM syndrome; antipolysaccharide response; V-H GENES; HUMAN MONOCLONAL-ANTIBODY; VARIABLE REGION GENES; TOLL-LIKE RECEPTORS; HYPER-IGM SYNDROME; INFLUENZAE TYPE-B; BONE-MARROW; CAPSULAR POLYSACCHARIDE; HUMAN SPLEEN; HUMAN NAIVE;

D O I：

10.1146/annurev.immunol.021908.132607

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Human marginal zone (MZ) B cells are, in a sense, a new entity. Although they share many properties with their mouse counterpart, they also display striking differences, such as the capacity to recirculate and the presence of somatic mutations in their B cell receptor. These differences are the reason they are often not considered a separate, rodent-like B cell lineage, but rather are considered IgM memory B cells. We review here our present knowledge concerning this subset and the arguments in favor of the proposition that humans have evolved for their MZ B cell compartment a separate 13 cell Population that develops and diversifies its Ig receptor during ontogeny outside T-dependent or T-independent immune responses.

引用

页码：267 / 285

页数：19

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