共 43 条
Role of G-protein-coupled signaling in the induction and regulation of dendritic cell function by Toxoplasma gondii
被引:13
作者:

Aliberti, J
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h-index: 0
机构:
NIAID, Immunobiol Sect, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA NIAID, Immunobiol Sect, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA

Sher, A
论文数: 0 引用数: 0
h-index: 0
机构:
NIAID, Immunobiol Sect, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA NIAID, Immunobiol Sect, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA
机构:
[1] NIAID, Immunobiol Sect, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA
关键词:
Toxoplasma gondii;
IL-12/CCR5;
dendritic cell;
lipoxin;
D O I:
10.1016/S1286-4579(02)01618-0
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
The induction of IL-12 from dendritic cells (DCs) is thought to be a critical step in the initiation of IFN-gamma-dependent cell-mediated immunity to many intracellular pathogens. We have studied this response using an in vivo model in which IL-12 production by splenic CD8alpha(+) DCs is followed after systemic injection of a soluble extract (STAg) of the protozoan parasite Toxoplasma gondii. Our findings indicate that G-protein-coupled signaling through the chemokine receptor CCR5 plays a major role in the induction of IL-12 from these cells and that downregulation of CCR5 function through endogenously produced lipoxin explains the loss of responsiveness (paralysis) seen upon STAg reinjection. Recent data on the inductive and regulatory pathways involved and their role in governing host resistance to parasite infection in vivo will be discussed. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
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页码:991 / 997
页数:7
相关论文
共 43 条
[1]
Lipoxin-mediated inhibition of IL-12 production by DCs: a mechanism for regulation of microbial immunity
[J].
Aliberti, J
;
Hieny, S
;
Sousa, CRE
;
Serhan, CN
;
Sher, A
.
NATURE IMMUNOLOGY,
2002, 3 (01)
:76-82

Aliberti, J
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Inst Allergy & Infect Dis, Lab Parasit Dis, Immunobiol Sect, NIH, Bethesda, MD 20892 USA Natl Inst Allergy & Infect Dis, Lab Parasit Dis, Immunobiol Sect, NIH, Bethesda, MD 20892 USA

Hieny, S
论文数: 0 引用数: 0
h-index: 0
机构: Natl Inst Allergy & Infect Dis, Lab Parasit Dis, Immunobiol Sect, NIH, Bethesda, MD 20892 USA

Sousa, CRE
论文数: 0 引用数: 0
h-index: 0
机构: Natl Inst Allergy & Infect Dis, Lab Parasit Dis, Immunobiol Sect, NIH, Bethesda, MD 20892 USA

Serhan, CN
论文数: 0 引用数: 0
h-index: 0
机构: Natl Inst Allergy & Infect Dis, Lab Parasit Dis, Immunobiol Sect, NIH, Bethesda, MD 20892 USA

Sher, A
论文数: 0 引用数: 0
h-index: 0
机构: Natl Inst Allergy & Infect Dis, Lab Parasit Dis, Immunobiol Sect, NIH, Bethesda, MD 20892 USA
[2]
CCR5 provides a signal for microbial induced production of IL-12 by CD8α+ dendritic cells
[J].
Aliberti, J
;
Sousa, CRE
;
Schito, M
;
Hieny, S
;
Wells, T
;
Huffnagle, GB
;
Sher, A
.
NATURE IMMUNOLOGY,
2000, 1 (01)
:83-87

Aliberti, J
论文数: 0 引用数: 0
h-index: 0
机构: NIAID, Immunobiol Sect, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA

Sousa, CRE
论文数: 0 引用数: 0
h-index: 0
机构: NIAID, Immunobiol Sect, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA

Schito, M
论文数: 0 引用数: 0
h-index: 0
机构: NIAID, Immunobiol Sect, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA

Hieny, S
论文数: 0 引用数: 0
h-index: 0
机构: NIAID, Immunobiol Sect, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA

Wells, T
论文数: 0 引用数: 0
h-index: 0
机构: NIAID, Immunobiol Sect, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA

Huffnagle, GB
论文数: 0 引用数: 0
h-index: 0
机构: NIAID, Immunobiol Sect, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA

Sher, A
论文数: 0 引用数: 0
h-index: 0
机构: NIAID, Immunobiol Sect, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA
[3]
Rapid recruitment of neutrophils containing prestored IL-12 during microbial infection
[J].
Bliss, SK
;
Butcher, BA
;
Denkers, EY
.
JOURNAL OF IMMUNOLOGY,
2000, 165 (08)
:4515-4521

Bliss, SK
论文数: 0 引用数: 0
h-index: 0
机构:
Cornell Univ, Coll Vet Med, Dept Microbiol & Immunol, Ithaca, NY 14853 USA Cornell Univ, Coll Vet Med, Dept Microbiol & Immunol, Ithaca, NY 14853 USA

Butcher, BA
论文数: 0 引用数: 0
h-index: 0
机构:
Cornell Univ, Coll Vet Med, Dept Microbiol & Immunol, Ithaca, NY 14853 USA Cornell Univ, Coll Vet Med, Dept Microbiol & Immunol, Ithaca, NY 14853 USA

Denkers, EY
论文数: 0 引用数: 0
h-index: 0
机构:
Cornell Univ, Coll Vet Med, Dept Microbiol & Immunol, Ithaca, NY 14853 USA Cornell Univ, Coll Vet Med, Dept Microbiol & Immunol, Ithaca, NY 14853 USA
[4]
Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice
[J].
Boring, L
;
Gosling, J
;
Chensue, SW
;
Kunkel, SL
;
Farese, RV
;
Broxmeyer, HE
;
Charo, IF
.
JOURNAL OF CLINICAL INVESTIGATION,
1997, 100 (10)
:2552-2561

Boring, L
论文数: 0 引用数: 0
h-index: 0
机构: UNIV CALIF SAN FRANCISCO,GLADSTONE INST CARDIOVASC DIS,SAN FRANCISCO,CA 94141

Gosling, J
论文数: 0 引用数: 0
h-index: 0
机构: UNIV CALIF SAN FRANCISCO,GLADSTONE INST CARDIOVASC DIS,SAN FRANCISCO,CA 94141

Chensue, SW
论文数: 0 引用数: 0
h-index: 0
机构: UNIV CALIF SAN FRANCISCO,GLADSTONE INST CARDIOVASC DIS,SAN FRANCISCO,CA 94141

Kunkel, SL
论文数: 0 引用数: 0
h-index: 0
机构: UNIV CALIF SAN FRANCISCO,GLADSTONE INST CARDIOVASC DIS,SAN FRANCISCO,CA 94141

Farese, RV
论文数: 0 引用数: 0
h-index: 0
机构: UNIV CALIF SAN FRANCISCO,GLADSTONE INST CARDIOVASC DIS,SAN FRANCISCO,CA 94141

Broxmeyer, HE
论文数: 0 引用数: 0
h-index: 0
机构: UNIV CALIF SAN FRANCISCO,GLADSTONE INST CARDIOVASC DIS,SAN FRANCISCO,CA 94141

Charo, IF
论文数: 0 引用数: 0
h-index: 0
机构: UNIV CALIF SAN FRANCISCO,GLADSTONE INST CARDIOVASC DIS,SAN FRANCISCO,CA 94141
[5]
Activation of the formyl peptide receptor by the HIV-derived peptide T-20 suppresses interleukin-12 p70 production by human monocytes
[J].
Braun, MC
;
Wang, JM
;
Lahey, E
;
Rabin, RL
;
Kelsall, BL
.
BLOOD,
2001, 97 (11)
:3531-3536

Braun, MC
论文数: 0 引用数: 0
h-index: 0
机构: NIAID, Mucosal Immun Sect, Immune Cell Interact Unit, NIH, Bethesda, MD 20892 USA

Wang, JM
论文数: 0 引用数: 0
h-index: 0
机构: NIAID, Mucosal Immun Sect, Immune Cell Interact Unit, NIH, Bethesda, MD 20892 USA

Lahey, E
论文数: 0 引用数: 0
h-index: 0
机构: NIAID, Mucosal Immun Sect, Immune Cell Interact Unit, NIH, Bethesda, MD 20892 USA

Rabin, RL
论文数: 0 引用数: 0
h-index: 0
机构: NIAID, Mucosal Immun Sect, Immune Cell Interact Unit, NIH, Bethesda, MD 20892 USA

Kelsall, BL
论文数: 0 引用数: 0
h-index: 0
机构: NIAID, Mucosal Immun Sect, Immune Cell Interact Unit, NIH, Bethesda, MD 20892 USA
[6]
Regulation of interleukin-12 production by G-protein-coupled receptors
[J].
Braun, MC
;
Kelsall, BL
.
MICROBES AND INFECTION,
2001, 3 (02)
:99-107

Braun, MC
论文数: 0 引用数: 0
h-index: 0
机构:
NIAID, Immune Cell Interact Unit, Mucosal Immun Sect, Clin Invest Lab,NIH, Bethesda, MD 20892 USA NIAID, Immune Cell Interact Unit, Mucosal Immun Sect, Clin Invest Lab,NIH, Bethesda, MD 20892 USA

Kelsall, BL
论文数: 0 引用数: 0
h-index: 0
机构:
NIAID, Immune Cell Interact Unit, Mucosal Immun Sect, Clin Invest Lab,NIH, Bethesda, MD 20892 USA NIAID, Immune Cell Interact Unit, Mucosal Immun Sect, Clin Invest Lab,NIH, Bethesda, MD 20892 USA
[7]
Inactivation of LRG-47 and IRG-47 reveals a family of interferon γ-inducible genes with essential, pathogen-specific roles in resistance to infection
[J].
Collazo, CM
;
Yap, GS
;
Sempowski, GD
;
Lusby, KC
;
Tessarollo, L
;
Woude, GFV
;
Sher, A
;
Taylor, GA
.
JOURNAL OF EXPERIMENTAL MEDICINE,
2001, 194 (02)
:181-187

Collazo, CM
论文数: 0 引用数: 0
h-index: 0
机构: Duke Univ, Med Ctr, Dept Med, Div Rheumatol Allergy & Clin Immunol, Durham, NC 27710 USA

Yap, GS
论文数: 0 引用数: 0
h-index: 0
机构: Duke Univ, Med Ctr, Dept Med, Div Rheumatol Allergy & Clin Immunol, Durham, NC 27710 USA

Sempowski, GD
论文数: 0 引用数: 0
h-index: 0
机构: Duke Univ, Med Ctr, Dept Med, Div Rheumatol Allergy & Clin Immunol, Durham, NC 27710 USA

Lusby, KC
论文数: 0 引用数: 0
h-index: 0
机构: Duke Univ, Med Ctr, Dept Med, Div Rheumatol Allergy & Clin Immunol, Durham, NC 27710 USA

Tessarollo, L
论文数: 0 引用数: 0
h-index: 0
机构: Duke Univ, Med Ctr, Dept Med, Div Rheumatol Allergy & Clin Immunol, Durham, NC 27710 USA

Woude, GFV
论文数: 0 引用数: 0
h-index: 0
机构: Duke Univ, Med Ctr, Dept Med, Div Rheumatol Allergy & Clin Immunol, Durham, NC 27710 USA

Sher, A
论文数: 0 引用数: 0
h-index: 0
机构: Duke Univ, Med Ctr, Dept Med, Div Rheumatol Allergy & Clin Immunol, Durham, NC 27710 USA

Taylor, GA
论文数: 0 引用数: 0
h-index: 0
机构: Duke Univ, Med Ctr, Dept Med, Div Rheumatol Allergy & Clin Immunol, Durham, NC 27710 USA
[8]
A synthetic peptide derived from human immunodeficiency virus type 1 gp120 downregulates the expression and function of chemokine receptors CCR5 and CXCR4 in monocytes by activating the 7-transmembrane G-protein-coupled receptor FPRL1/LXA4R
[J].
Deng, XY
;
Ueda, H
;
Su, SB
;
Gong, WH
;
Dunlop, NM
;
Gao, JL
;
Murphy, PM
;
Wang, JM
.
BLOOD,
1999, 94 (04)
:1165-1173

Deng, XY
论文数: 0 引用数: 0
h-index: 0
机构: NCI, Frederick Canc Res & Dev Ctr, Mol Immunoregulat Lab, Div Basic Sci, Frederick, MD 21702 USA

Ueda, H
论文数: 0 引用数: 0
h-index: 0
机构: NCI, Frederick Canc Res & Dev Ctr, Mol Immunoregulat Lab, Div Basic Sci, Frederick, MD 21702 USA

Su, SB
论文数: 0 引用数: 0
h-index: 0
机构: NCI, Frederick Canc Res & Dev Ctr, Mol Immunoregulat Lab, Div Basic Sci, Frederick, MD 21702 USA

Gong, WH
论文数: 0 引用数: 0
h-index: 0
机构: NCI, Frederick Canc Res & Dev Ctr, Mol Immunoregulat Lab, Div Basic Sci, Frederick, MD 21702 USA

Dunlop, NM
论文数: 0 引用数: 0
h-index: 0
机构: NCI, Frederick Canc Res & Dev Ctr, Mol Immunoregulat Lab, Div Basic Sci, Frederick, MD 21702 USA

Gao, JL
论文数: 0 引用数: 0
h-index: 0
机构: NCI, Frederick Canc Res & Dev Ctr, Mol Immunoregulat Lab, Div Basic Sci, Frederick, MD 21702 USA

Murphy, PM
论文数: 0 引用数: 0
h-index: 0
机构: NCI, Frederick Canc Res & Dev Ctr, Mol Immunoregulat Lab, Div Basic Sci, Frederick, MD 21702 USA

Wang, JM
论文数: 0 引用数: 0
h-index: 0
机构: NCI, Frederick Canc Res & Dev Ctr, Mol Immunoregulat Lab, Div Basic Sci, Frederick, MD 21702 USA
[9]
PATHO-PHYSIOLOGY OF TOXOPLASMOSIS
[J].
FRENKEL, JK
.
PARASITOLOGY TODAY,
1988, 4 (10)
:273-278

FRENKEL, JK
论文数: 0 引用数: 0
h-index: 0
[10]
Inducible expression of Stat4 in dendritic cells and macrophages and its critical role in innate and adaptive immune responses
[J].
Fukao, T
;
Frucht, DM
;
Yap, G
;
Gadina, M
;
O'Shea, JJ
;
Koyasu, S
.
JOURNAL OF IMMUNOLOGY,
2001, 166 (07)
:4446-4455

Fukao, T
论文数: 0 引用数: 0
h-index: 0
机构: Keio Univ, Sch Med, Dept Microbiol & Immunol, Shinjuku Ku, Tokyo 1608582, Japan

Frucht, DM
论文数: 0 引用数: 0
h-index: 0
机构: Keio Univ, Sch Med, Dept Microbiol & Immunol, Shinjuku Ku, Tokyo 1608582, Japan

Yap, G
论文数: 0 引用数: 0
h-index: 0
机构: Keio Univ, Sch Med, Dept Microbiol & Immunol, Shinjuku Ku, Tokyo 1608582, Japan

Gadina, M
论文数: 0 引用数: 0
h-index: 0
机构: Keio Univ, Sch Med, Dept Microbiol & Immunol, Shinjuku Ku, Tokyo 1608582, Japan

O'Shea, JJ
论文数: 0 引用数: 0
h-index: 0
机构: Keio Univ, Sch Med, Dept Microbiol & Immunol, Shinjuku Ku, Tokyo 1608582, Japan

Koyasu, S
论文数: 0 引用数: 0
h-index: 0
机构: Keio Univ, Sch Med, Dept Microbiol & Immunol, Shinjuku Ku, Tokyo 1608582, Japan