Structure of an ovine interferon receptor and its expression in endometrium

被引：13

作者：

Kaluz, S

Fisher, PA

Kaluzova, M

Sheldrick, EL

Flint, APF

机构：

[1] Dept. of Physiol. and Environ. Sci., University of Nottingham

来源：

JOURNAL OF MOLECULAR ENDOCRINOLOGY | 1996年 / 17卷 / 03期

关键词：

D O I：

10.1677/jme.0.0170207

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A sheep type I interferon receptor (oIFNAR1) cDNA was isolated from a lambda-ZAP library using a reverse transcription (RT)-PCR product probe generated from oestrous endometrial RNA. The oIFNAR1 cDNA was 79, 66 and 95% homologous to human, murine and bovine IFNAR1 cDNAs respectively. The encoded receptor was a 560-amino acid transmembrane protein 80, 66 and 95% similar to human, murine and bovine IFNAR1 respectively. Northern blot analysis of endometrial mRNA revealed the presence of 6.5, 4.3 and 3.7 kb transcripts. Using semi-quantitative RT-PCR the oIFNAR1 mRNA was not found to be downregulated after 72 h treatment with bovine recombinant IFN-alpha(I) in in vitro experiments with endometrial explants.

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收藏

页码：207 / 215

页数：9

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