An approach to the Paal-Knorr pyrroles synthesis catalyzed by Sc(OTf)3 under solvent-free conditions

被引：208

作者：

Chen, Jiuxi

Wu, Huayue

Zheng, Zhiguo

Jin, Can

Zhang, Xingxian

Su, Weike ^{[1
]}

机构：

[1] Wenzhou Univ, Coll Chem & Mat Sci, Wenzhou 325027, Peoples R China

[2] Zhejiang Univ Technol, Coll Pharmaceut Sci, Zhejiang Key Lab Pharmaceut Engn, Hangzhou 310014, Peoples R China

[3] Zhejiang Hisoar Pharmaceut Co Ltd, Taizhou 318000, Peoples R China

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 30期

基金：

中国国家自然科学基金;

关键词：

scandium triflate; pyrrole; Paal-Knorr; solvent-free conditions;

D O I：

10.1016/j.tetlet.2006.05.085

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile synthesis of N-substituted pyrroles by the Paal-Knorr condensation has been accomplished using a simple procedure. Among different metal triflates screened, 1 mol % Sc(OT)(3) efficiently promoted the reaction to give excellent yield (89-98%) under mild reaction conditions. Additionally, Sc(OTf)(3) could be recovered easily after the reactions and reused without evident loss in activity. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：5383 / 5387

页数：5

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