Developmental and pathological angiogenesis in the central nervous system

被引：166

作者：

Vallon, Mario ^{[1
]}

Chang, Junlei ^{[1
]}

Zhang, Haijing ^{[1
]}

Kuo, Calvin J. ^{[1
]}

机构：

[1] Stanford Univ, Div Hematol, Sch Med, Stanford, CA 94305 USA

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2014年 / 71卷 / 18期

关键词：

Central nervous system; Angiogenesis; Brain tumors; Embryogenesis; Ischemic stroke; ENDOTHELIAL GROWTH-FACTOR; BLOOD-BRAIN-BARRIER; HEREDITARY HEMORRHAGIC TELANGIECTASIA; MIDDLE CEREBRAL-ARTERY; PROTEIN-COUPLED RECEPTOR; TRANSGENIC MOUSE MODEL; MCA-OCCLUSION MODEL; TGF-BETA; FACTOR EXPRESSION; RAT-BRAIN;

D O I：

10.1007/s00018-014-1625-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Angiogenesis, the formation of new blood vessels from pre-existing vessels, in the central nervous system (CNS) is seen both as a normal physiological response as well as a pathological step in disease progression. Formation of the blood-brain barrier (BBB) is an essential step in physiological CNS angiogenesis. The BBB is regulated by a neurovascular unit (NVU) consisting of endothelial and perivascular cells as well as vascular astrocytes. The NVU plays a critical role in preventing entry of neurotoxic substances and regulation of blood flow in the CNS. In recent years, research on numerous acquired and hereditary disorders of the CNS has increasingly emphasized the role of angiogenesis in disease pathophysiology. Here, we discuss molecular mechanisms of CNS angiogenesis during embryogenesis as well as various pathological states including brain tumor formation, ischemic stroke, arteriovenous malformations, and neurodegenerative diseases.

引用

页码：3489 / 3506

页数：18

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