Phospholipid flip-flop in biogenic membranes: what is needed to connect opposite sides

被引：39

作者：

Kol, MA ^{[1
]}

de Kruijff, B ^{[1
]}

de Kroon, AIPM ^{[1
]}

机构：

[1] Univ Utrecht, Inst Biomembranes, Ctr Biomembranes & Lipid Enzymol, Dept Biochem Membranes, NL-3584 CH Utrecht, Netherlands

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2002年 / 13卷 / 03期

关键词：

bacterial membrane; endoplasmic reticulum; flippase; membrane biogenesis; phospholipids;

D O I：

10.1016/S1084-9521(02)00044-7

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Phospholipids are synthesized in biogenic membranes, but only on one leaflet of the bilayer To support balanced growth of the membrane, phospholipid translocation, or flip-flop, has to occur. Though consensus has been reached that flip-flop is most likely mediated by (a) membrane-associated protein(s), a dedicated flippase has not been identified yet in any biogenic membrane. The characteristics of the flip-flop process are summarized, and possible mechanisms, including the need for a dedicated flippase, are discussed.

引用

页码：163 / 170

页数：8

共 60 条

[1] Association between the endoplasmic reticulum and mitochondria of yeast facilitates interorganelle transport of phospholipids through membrane contact [J].