The Virome of the Human Respiratory Tract

被引：51

作者：

Wylie, Kristine M. ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Pediat, McDonnell Genome Inst, Campus Box 8208,660 South Euclid Ave, St Louis, MO 63110 USA

来源：

CLINICS IN CHEST MEDICINE | 2017年 / 38卷 / 01期

关键词：

Virus; Infection; Lung; Culture independent; Chronic lung disease; Diagnostics; High-throughput sequencing; CYSTIC-FIBROSIS; ENTEROVIRUS D68; VIRUSES; METAGENOMICS; COMMUNITY; IDENTIFICATION; EXACERBATIONS; INFECTIONS; BACTERIAL; CHILDREN;

D O I：

10.1016/j.ccm.2016.11.001

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

The human respiratory tract virome is defined here as the viruses present in the human respiratory tract that can infect human cells. Sensitive, culture-independent molecular assays (polymerase chain reaction and high-throughput sequencing) reveal that in addition to common viruses that cause acute, symptomatic infections, the virome also includes viruses that do not cause clinical symptoms, have unknown pathogenic effect, or cause symptoms but are not among the most common viral respiratory tract pathogens. These molecular tools provide means for better defining the virome and studying the effects of viral infections on the dynamics of chronic lung diseases.

引用

页码：11 / +

页数：10

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