Gamma-secretase as a pharmacological target in Alzheimer disease research: When, why and how?

被引：14

作者：

Ziani-Cherif, Chewki ^{[1
]}

Mostefa-Kara, Bachir ^{[1
]}

Brixi-Gormat, Fatima Z. ^{[1
]}

机构：

[1] Univ Abou Bekr Balkaid, Lab Catalyse & Chim Fine, Tilimsen 13000, Algeria

来源：

CURRENT PHARMACEUTICAL DESIGN | 2006年 / 12卷 / 33期

关键词：

Alzheimer disease; amyloid beta precursor protein; amyloid beta; gamma-secretase; presenilins; gamma-secretase inhibitors; non-steroidal anti-inflammatory drugs;

D O I：

10.2174/138161206778792994

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Alzheimer disease (AD) is characterized by excessive deposition of amyloid beta-peptides (A beta peptides) in the form of senile plaques as well as neurofibrillary tangles (NFTs) in the brain. In the amyloidogenic pathway, the amyloid-beta precursor protein (APP) is cleaved by beta-secretase first, followed by gamma-secretase cleavage producing therefore A beta. This review summarizes the recent findings in the AD field and focuses on the different gamma-secretase inhibitors that have been developed as a therapeutic approach toward AD.

引用

页码：4313 / 4335

页数：23

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