Potassium channels and the atomic basis of selective ion conduction (Nobel lecture)
被引:305
作者:
MacKinnon, R
论文数: 0引用数: 0
h-index: 0
机构:
Rockefeller Univ, Howard Hughes Med Inst, Lab Mol Neurobiol & Biophys, New York, NY 10021 USARockefeller Univ, Howard Hughes Med Inst, Lab Mol Neurobiol & Biophys, New York, NY 10021 USA
MacKinnon, R
[1
]
机构:
[1] Rockefeller Univ, Howard Hughes Med Inst, Lab Mol Neurobiol & Biophys, New York, NY 10021 USA
ion channels;
membranes;
Nobel Lecture;
protein structures;
structure elucidation;
D O I:
10.1002/anie.200400662
中图分类号:
O6 [化学];
学科分类号:
0703 ;
摘要:
Closing in on the facts: The key to understanding the transport of K + ions through the cell membrane lay in the structure elucidation of a K+ ion channel (see picture). The studies of Roderick MacKinnon and co-workers have contributed significantly to the understanding of this research area. In his Nobel Lecture, he describes the structural characteristics of K+ ion channels as well as a possible mechanism for ion conduction.