Potassium channels and the atomic basis of selective ion conduction (Nobel lecture)

被引:305
作者
MacKinnon, R [1 ]
机构
[1] Rockefeller Univ, Howard Hughes Med Inst, Lab Mol Neurobiol & Biophys, New York, NY 10021 USA
关键词
ion channels; membranes; Nobel Lecture; protein structures; structure elucidation;
D O I
10.1002/anie.200400662
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Closing in on the facts: The key to understanding the transport of K + ions through the cell membrane lay in the structure elucidation of a K+ ion channel (see picture). The studies of Roderick MacKinnon and co-workers have contributed significantly to the understanding of this research area. In his Nobel Lecture, he describes the structural characteristics of K+ ion channels as well as a possible mechanism for ion conduction.
引用
收藏
页码:4265 / 4277
页数:13
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共 70 条
[1]  
Accardi A, 2004, BIOPHYS J, V86, p286A
[2]   CHARGE MOVEMENT ASSOCIATED WITH OPENING AND CLOSING OF ACTIVATION GATES OF NA CHANNELS [J].
ARMSTRONG, CM ;
BEZANILLA, F .
JOURNAL OF GENERAL PHYSIOLOGY, 1974, 63 (05) :533-552
[3]   SODIUM-CHANNELS AND GATING CURRENTS [J].
ARMSTRONG, CM .
PHYSIOLOGICAL REVIEWS, 1981, 61 (03) :644-683
[4]   DESTRUCTION OF SODIUM CONDUCTANCE INACTIVATION IN SQUID AXONS PERFUSED WITH PRONASE [J].
ARMSTRONG, CM ;
BEZANILLA, F ;
ROJAS, E .
JOURNAL OF GENERAL PHYSIOLOGY, 1973, 62 (04) :375-391
[5]   INACTIVATION OF SODIUM CHANNEL .2. GATING CURRENT EXPERIMENTS [J].
ARMSTRONG, CM ;
BEZANILLA, F .
JOURNAL OF GENERAL PHYSIOLOGY, 1977, 70 (05) :567-590
[7]   IONIC PORES, GATES, AND GATING CURRENTS [J].
ARMSTRONG, CM .
QUARTERLY REVIEWS OF BIOPHYSICS, 1974, 7 (02) :179-210
[8]   INNER QUATERNARY AMMONIUM ION RECEPTOR IN POTASSIUM CHANNELS OF NODE OF RANVIER [J].
ARMSTRONG, CM ;
HILLE, B .
JOURNAL OF GENERAL PHYSIOLOGY, 1972, 59 (04) :388-+
[9]   A COMPONENT OF CALCIUM-ACTIVATED POTASSIUM CHANNELS ENCODED BY THE DROSOPHILA-SLO LOCUS [J].
ATKINSON, NS ;
ROBERTSON, GA ;
GANETZKY, B .
SCIENCE, 1991, 253 (5019) :551-555
[10]   Crystal structure of Escherichia coli MscS, a voltage-modulated and mechanosensitive channel [J].
Bass, RB ;
Strop, P ;
Barclay, M ;
Rees, DC .
SCIENCE, 2002, 298 (5598) :1582-1587