Antipsychotic drugs clozapine and olanzapine upregulate bcl-2 mRNA and protein in rat frontal cortex and hippocampus

被引：72

作者：

Bai, O

Zhang, HH

Li, XM

机构：

[1] Univ Saskatchewan, Dept Psychiat, Neuropsychiat Res Unit, Saskatoon, SK S7N 5E4, Canada

[2] Jilin Univ, Teaching Hosp 1, Changchun 130021, Peoples R China

来源：

BRAIN RESEARCH | 2004年 / 1010卷 / 1-2期

关键词：

bcl-2; atypical antipsychotic drug; frontal cortex; hippocampus; in situ hybridization; western blot;

D O I：

10.1016/j.brainres.2004.02.064

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To investigate whether atypical antipsychotic drugs exert an effect on the neuroprotective protein Bcl-2, rats were chronically treated with clozapine or olanzapine for 28 days. The expression of bcl-2 mRNA and Bcl-2 protein was determined, respectively, by in situ hybridization in tissue sections and Western blot on tissue samples from rat frontal cortex and hippocampus. The bcl-2 mRNA positive cells were increased in these regions after drug treatments, and quantitative analysis revealed that the upregulation of bcl-2 mRNA and Bcl-2 protein is significantly greater than in vehicle control (p < 0.05 or p < 0.01). It is demonstrated that neuroprotective protein Bcl-2 is involved in the action of atypical antipsychotic drugs, and might represent a neuroprotective mechanism of these drugs. (C) 2004 Elsevier B.V All rights reserved.

引用

页码：81 / 86

页数：6

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