Aup1, a novel gene on mouse chromosome 6 and human chromosome 2p13

被引:7
作者
Jang, WH
Weber, JS
Bashir, R
Bushby, K
Meisler, MH
机构
[1] UNIV MICHIGAN,DEPT HUMAN GENET,ANN ARBOR,MI 48109
[2] UNIV NEWCASTLE UPON TYNE,DEPT HUMAN GENET,NEWCASTLE TYNE NE2 4AA,TYNE & WEAR,ENGLAND
基金
英国医学研究理事会;
关键词
D O I
10.1006/geno.1996.0477
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
We have cloned a novel mouse cDNA, Aup1, encoding a predicted protein of 410 amino acid residues. The 1.5-kb Aup1 transcript is ubiquitously expressed in mouse tissues, An evolutionary relationship to the Caenorhabditis elegans predicted protein F44b9.5 is indicated by the 35% identity and 53% conservation of the amino acid sequences. Nineteen related human ESTs spanning 80% of the protein have also been identified, with a predicted amino acid sequence identity of 86% between the human and the mouse proteins. The gene has been mapped to a conserved linkage group on human chromosome 2p13 and mouse Chromosome 6. Aup1 was eliminated as a candidate gene for two closely linked disorders, human LGMD2B and mouse mnd2. (C) 1996 Academic Press, Inc.
引用
收藏
页码:366 / 368
页数:3
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