Roosting ecology and variation in adaptive and innate immune system function in the Brazilian free-tailed bat (Tadarida brasiliensis)

被引:68
作者
Allen, Louise C. [1 ]
Turmelle, Amy S. [2 ]
Mendonca, Mary T. [3 ]
Navara, Kristen J. [3 ,4 ]
Kunz, Thomas H. [1 ]
McCracken, Gary F. [2 ]
机构
[1] Boston Univ, Ctr Ecol & Conservat Biol, Boston, MA 02215 USA
[2] Univ Tennessee, Dept Ecol & Evolutionary Biol, Knoxville, TN 37996 USA
[3] Auburn Univ, Dept Biol Sci, Auburn, AL 36849 USA
[4] Univ Georgia, Dept Poultry Sci, Athens, GA 30602 USA
来源
JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMS AND ENVIRONMENTAL PHYSIOLOGY | 2009年 / 179卷 / 03期
关键词
Artificial roosts; Bactericidal ability; Bats; Immune response; Phytohaemagglutinin; LOUIS ENCEPHALITIS-VIRUS; BIG BROWN BATS; HISTOPLASMA-CAPSULATUM; FRUIT BATS; TRADE-OFFS; INFECTION; IMMUNOCOMPETENCE; IMMUNOLOGY; EVOLUTION; RESERVOIR;
D O I
10.1007/s00360-008-0315-3
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Bats have recently been implicated as reservoirs of important emerging diseases. However, few studies have examined immune responses in bats, and even fewer have evaluated these responses in an ecological context. We examined aspects of both innate and adaptive immune response in adult female Brazilian free-tailed bats (Tadarida brasiliensis) at four maternity roosts (two natural caves and two human-made bridges) in south-central Texas. Immune measurements included in vitro bactericidal ability of whole blood and in vivo T cell mediated response to mitogenic challenge. Bactericidal activity in T. brasiliensis varied with roosting ecology, but appears to be sensitive to colony-level effects. Blood from females living at one cave had significantly lower bactericidal ability than blood from females at three other sites. T cell mediated response in this species was associated with variation in roost ecology, with females from two caves having greater responses than females from two bridges. T cell mediated response and bactericidal activity were negatively correlated with one another within individuals that were tested for both. Variation in immunological response of T. brasiliensis is important for understanding the influence of the environment on the frequency and distribution of immunologically competent individuals and for understanding disease-host dynamics in this and other colonial species.
引用
收藏
页码:315 / 323
页数:9
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